Al Ain 3-8 Al Duhail SC *
| 15.05.2018 | Al Duhail SC | 4-1 | Al Ain | |
| 08.05.2018 | Al Ain | 2-4 | Al Duhail SC | |
*Al Sadd SC 4-3 Al Ahli Jeddah
| 14.05.2018 | Al Ahli Jeddah | 2-2 | Al Sadd SC | |
| 07.05.2018 | Al Sadd SC | 2-1 | Al Ahli Jeddah | |
Buriram United 3-4 Jeonbuk Hyundai M. *
| 15.05.2018 | Jeonbuk Hyundai M. | 2-0 | Buriram United | |
| 08.05.2018 | Buriram United | 3-2 | Jeonbuk Hyundai M. | |
*Tianjin Quanjian 2-2 Guangzhou Evergrande
| 15.05.2018 | Guangzhou Evergrande | 2-2 | Tianjin Quanjian | |
| 08.05.2018 | Tianjin Quanjian | 0-0 | Guangzhou Evergrande | |
Jazira Abu Dhabi 4-4 Persepolis FC *
| 14.05.2018 | Persepolis FC | 2-1 | Jazira Abu Dhabi | |
| 07.05.2018 | Jazira Abu Dhabi | 3-2 | Persepolis FC | |
*Kashima Antlers 4-3 Shanghai SIPG
| 16.05.2018 | Shanghai SIPG | 2-1 | Kashima Antlers | |
| 09.05.2018 | Kashima Antlers | 3-1 | Shanghai SIPG | |
Ulsan Hyundai 1-3 Suwon Bluewings *
| 16.05.2018 | Suwon Bluewings | 3-0 | Ulsan Hyundai | |
| 09.05.2018 | Ulsan Hyundai | 1-0 | Suwon Bluewings | |
Zob Ahan 2-3 Esteghlal Tehran *
| 15.05.2018 | Esteghlal Tehran | 3-1 | Zob Ahan | |
| 08.05.2018 | Zob Ahan | 1-0 | Esteghlal Tehran | |