*ES Sétif 3-2 Al Ansar Club
| 26.11.2008 | Al Ansar Club | 0-0 | ES Sétif | |
| 27.10.2008 | ES Sétif | 3-2 | Al Ansar Club | |
| 23.11.2008 | Al Arabi Kuwait | CANC | Al Hilal Al Sudani | |
| 27.10.2008 | Al Hilal Al Sudani | CANC | Al Arabi Kuwait | |
| 25.11.2008 | Al Hazm | CANC | Qadisiya Kuwait | |
| 30.10.2008 | Qadisiya Kuwait | CANC | Al Hazm | |
| 12.11.2008 | Sha'ab Sharjah | CANC | Al Merreikh SC | |
| 28.10.2008 | Al Merreikh SC | CANC | Sha'ab Sharjah | |
Wehdat Amman 3-1 Dhofar Salalah
| 25.11.2008 | Dhofar Salalah | 0-1 | Wehdat Amman | |
| 29.10.2008 | Wehdat Amman | 2-1 | Dhofar Salalah | |
*Esperance ST 0-0 Al Ahli Tripoli
| 26.11.2008 | Al Ahli Tripoli | 0-0/p.8-9 | Esperance ST | |
| 29.10.2008 | Esperance ST | 0-0 | Al Ahli Tripoli | |
Faisaly Amman 2-1 Wadi Al Nes
| 26.11.2008 | Wadi Al Nes | 1-2 | Faisaly Amman | |
| 30.10.2008 | Faisaly Amman | 0-0 | Wadi Al Nes | |
*Quwa Al Jawiya 2-1 Hassania Agadir
| 26.11.2008 | Hassania Agadir | 0-0 | Quwa Al Jawiya | |
| 28.10.2008 | Quwa Al Jawiya | 2-1 | Hassania Agadir | |
Kuwait SC 3-0 Hilal Hudaydah
| 24.11.2008 | Hilal Hudaydah | CANC | Kuwait SC | |
| 20.10.2008 | Kuwait SC | 3-0 ANL | Hilal Hudaydah | |
*Ismaily SC 7-2 Busaiteen
| 04.11.2008 | Busaiteen | 1-4 | Ismaily SC | |
| 29.10.2008 | Ismaily SC | 3-1 | Busaiteen | |
Ittihad Tripoli 2-3 US Monastir
| 26.11.2008 | US Monastir | 2-1 | Ittihad Tripoli | |
| 29.10.2008 | Ittihad Tripoli | 1-1 | US Monastir | |
CS Sfaxien 3-0 Nasr de Sebkha
| 26.11.2008 | Nasr de Sebkha | 0-0 | CS Sfaxien | |
| 29.10.2008 | CS Sfaxien | 3-0 | Nasr de Sebkha | |
Wydad Casablanca 5-0 Shabab Al Urdun
| 24.11.2008 | Shabab Al Urdun | 0-2 | Wydad Casablanca | |
| 28.10.2008 | Wydad Casablanca | 3-0 | Shabab Al Urdun | |
Raja Casablanca 6-2 Taliya Hama
| 24.11.2008 | Taliya Hama | 2-2 | Raja Casablanca | |
| 29.10.2008 | Raja Casablanca | 4-0 | Taliya Hama | |
USM Alger 4-3 Al Wahda Mecca
| 25.11.2008 | Al Wahda Mecca | 3-1 | USM Alger | |
| 28.10.2008 | USM Alger | 3-0 | Al Wahda Mecca | |
*Ittihad Aleppo 0-0 USM Annaba
| 26.11.2008 | USM Annaba | 0-0/p.2-4 | Ittihad Aleppo | |
| 28.10.2008 | Ittihad Aleppo | 0-0 | USM Annaba | |