*Al Hilal Al Sudani 4-3 Mamelodi Sundowns
| 11.05.2008 | Mamelodi Sundowns | 1-0 | Al Hilal Al Sudani | |
| 26.04.2008 | Al Hilal Al Sudani | 4-2 | Mamelodi Sundowns | |
*Enyimba FC 6-3 Club Africain Tunis
| 09.05.2008 | Club Africain Tunis | 2-1 | Enyimba FC | |
| 27.04.2008 | Enyimba FC | 5-1 | Club Africain Tunis | |
*Dynamos FC 2-0 Étoile Sahel Sousse
| 10.05.2008 | Étoile Sahel Sousse | 0-1 | Dynamos FC | |
| 27.04.2008 | Dynamos FC | 1-0 | Étoile Sahel Sousse | |
*Zamalek SC 4-2 Interclube Luanda
| 11.05.2008 | Interclube Luanda | 2-1 | Zamalek SC | |
| 26.04.2008 | Zamalek SC | 3-0 | Interclube Luanda | |
Ittihad Tripoli 2-3 TP Mazembe *
| 11.05.2008 | TP Mazembe | 2-0 | Ittihad Tripoli | |
| 27.04.2008 | Ittihad Tripoli | 2-1 | TP Mazembe | |
*Coton Sport 4-2 JS Kabylie
| 09.05.2008 | JS Kabylie | 2-1 | Coton Sport | |
| 26.04.2008 | Coton Sport | 3-0 | JS Kabylie | |
*ASEC Mimosas 1-1 OC Khouribga
| 11.05.2008 | OC Khouribga | 1-1 | ASEC Mimosas | |
| 27.04.2008 | ASEC Mimosas | 0-0 | OC Khouribga | |
Platinum Stars 2-3 Al Ahly Cairo *
| 11.05.2008 | Al Ahly Cairo | 2-0 | Platinum Stars | |
| 26.04.2008 | Platinum Stars | 2-1 | Al Ahly Cairo | |