Ittihad Tripoli 2-3 Ahly Cairo *
| 09.05.2010 | Ahly Cairo | 3-0 | Ittihad Tripoli | |
| 23.04.2010 | Ittihad Tripoli | 2-0 | Ahly Cairo | |
Al Hilal Al Sudani 1-4 Ismaily SC *
| 09.05.2010 | Ismaily SC | 3-1 | Al Hilal Al Sudani | |
| 25.04.2010 | Al Hilal Al Sudani | 0-1 | Ismaily SC | |
Djoliba AC 0-4 TP Mazembe
| 09.05.2010 | TP Mazembe | 3-0 | Djoliba AC | |
| 25.04.2010 | Djoliba AC | 0-1 | TP Mazembe | |
Dynamos FC 4-1 Gaborone United
| 08.05.2010 | Gaborone United | 0-0 | Dynamos FC | |
| 25.04.2010 | Dynamos FC | 4-1 | Gaborone United | |
*Esperance ST 4-1 Merreikh Al Sudan
| 08.05.2010 | Merreikh Al Sudan | 1-1 | Esperance ST | |
| 23.04.2010 | Esperance ST | 3-0 | Merreikh Al Sudan | |
JS Kabylie 3-2 Petro Atlético Luanda
| 09.05.2010 | Petro Atlético Luanda | 2-1 | JS Kabylie | |
| 25.04.2010 | JS Kabylie | 2-0 | Petro Atlético Luanda | |
SuperSport United 2-4 Heartland FC *
| 09.05.2010 | Heartland FC | 3-1 | SuperSport United | |
| 24.04.2010 | SuperSport United | 1-1 | Heartland FC | |