*Ahly Cairo 2-1 SuperSport United
| 02.04.2011 | SuperSport United | 1-0 | Ahly Cairo | |
| 18.03.2011 | Ahly Cairo | 2-0 | SuperSport United | |
*Al Hilal Al Sudani 4-1 Recreativo Caála
| 02.04.2011 | Recreativo Caála | 1-1 | Al Hilal Al Sudani | |
| 20.03.2011 | Al Hilal Al Sudani | 3-0 | Recreativo Caála | |
*ASC Jaraaf 4-1 Djoliba AC
| 02.04.2011 | Djoliba AC | 1-1 | ASC Jaraaf | |
| 20.03.2011 | ASC Jaraaf | 3-0 | Djoliba AC | |
*Esperance ST 5-2 ASPAC Cotonou
| 03.04.2011 | ASPAC Cotonou | 2-0 | Esperance ST | |
| 19.03.2011 | Esperance ST | 5-0 | ASPAC Cotonou | |
AS Vita Club 0-3 Coton Sport *
| 03.04.2011 | Coton Sport | 2-0 | AS Vita Club | |
| 20.03.2011 | AS Vita Club | 0-1 | Coton Sport | |
*ES Sétif 6-3 ASFA Yennega
| 03.04.2011 | ASFA Yennega | 3-4 | ES Sétif | |
| 19.03.2011 | ES Sétif | 2-0 | ASFA Yennega | |
JC Abidjan 0-3 Ittihad Tripoli *
| 04.04.2011 | JC Abidjan | 0-3 W.O. | Ittihad Tripoli | |
*Wydad Casablanca 2-0 Kano Pillars
| 03.04.2011 | Kano Pillars | 0-0 | Wydad Casablanca | |
| 20.03.2011 | Wydad Casablanca | 2-0 | Kano Pillars | |
Dynamos FC 4-4 MC Alger *
| 03.04.2011 | MC Alger | 3-0 | Dynamos FC | |
| 20.03.2011 | Dynamos FC | 4-1 | MC Alger | |
Merreikh Al Sudan 2-2 Interclube Luanda *
| 02.04.2011 | Interclube Luanda | 2-0/p.3-2 | Merreikh Al Sudan | |
| 19.03.2011 | Merreikh Al Sudan | 2-0 | Interclube Luanda | |
Motor Action FC 0-0 ASEC Mimosas *
| 19.03.2011 | Motor Action FC | 0-0/p.2-4 | ASEC Mimosas | |
Stade Malien 2-2 Raja Casablanca *
| 02.04.2011 | Raja Casablanca | 1-0 | Stade Malien | |
| 19.03.2011 | Stade Malien | 2-1 | Raja Casablanca | |
TP Mazembe 6-3 Simba SC
| 03.04.2011 | Simba SC | 2-3 ANL | TP Mazembe | |
| 20.03.2011 | TP Mazembe | 3-1 ANL | Simba SC | |
*ZESCO United 7-0 Young Buffaloes
| 02.04.2011 | Young Buffaloes | 0-2 | ZESCO United | |
| 19.03.2011 | ZESCO United | 5-0 | Young Buffaloes | |
*Club Africain Tunis 4-2 Zamalek SC
| 02.04.2011 | Zamalek SC | 2-1 ABD | Club Africain Tunis | |
| 20.03.2011 | Club Africain Tunis | 4-2 | Zamalek SC | |