Missile FC 3-4 Africa Sports *
| 04.03.2012 | Africa Sports | 2-0 | Missile FC | |
| 19.02.2012 | Missile FC | 3-2 | Africa Sports | |
AS GNN 0-1 Tonnerre d'Abomey *
| 04.03.2012 | Tonnerre d'Abomey | 1-0 | AS GNN | |
| 18.02.2012 | AS GNN | 0-0 | Tonnerre d'Abomey | |
ASFA Yennega 1-4 ASO Chlef *
| 02.03.2012 | ASO Chlef | 4-1 | ASFA Yennega | |
| 18.02.2012 | ASFA Yennega | 0-0 | ASO Chlef | |
*AS Vita Club 6-4 Atlético Olympique
| 18.03.2012 | Atlético Olympique | 4-1 | AS Vita Club | |
| 10.03.2012 | AS Vita Club | 5-0 | Atlético Olympique | |
CD Elá Nguema 0-6 Dolphins FC PH *
| 04.03.2012 | Dolphins FC PH | 3-0 | CD Elá Nguema | |
| 19.02.2012 | CD Elá Nguema | 0-3 | Dolphins FC PH | |
Coin Nord 2-4 Ethiopian Coffee *
| 04.03.2012 | Ethiopian Coffee | 4-1 | Coin Nord | |
| 18.02.2012 | Coin Nord | 1-0 | Ethiopian Coffee | |
AFAD Djékanou 2-0 Diables Noirs
| 06.03.2012 | Diables Noirs | 0-1 | AFAD Djékanou | |
| 19.02.2012 | AFAD Djékanou | 1-0 | Diables Noirs | |
*Diplomates FC 8ème Arr. 2-2 Les Astres FC
| 04.03.2012 | Les Astres FC | 2-1 | Diplomates FC 8ème Arr. | |
| 19.02.2012 | Diplomates FC 8ème Arr. | 1-0 | Les Astres FC | |
Green Mamba 2-8 FC Platinum (ZIM) *
| 03.03.2012 | FC Platinum (ZIM) | 4-0 | Green Mamba | |
| 19.02.2012 | Green Mamba | 2-4 | FC Platinum (ZIM) | |
Ports Auth. Freetown 0-1 Horoya AC *
| 04.03.2012 | Horoya AC | 1-0 | Ports Auth. Freetown | |
| 18.02.2012 | Ports Auth. Freetown | 0-0 | Horoya AC | |
Foullah Edifice 1-3 JSM Béjaia *
| 02.03.2012 | JSM Béjaia | 3-1 | Foullah Edifice | |
| 18.02.2012 | Foullah Edifice | 0-0 | JSM Béjaia | |
Mafunzo FC 0-5 Liga Muçulmana *
| 10.03.2012 | Liga Muçulmana | 3-0 | Mafunzo FC | |
| 19.02.2012 | Mafunzo FC | 0-2 | Liga Muçulmana | |
LISCR Monrovia 0-5 Berekum Chelsea *
| 04.03.2012 | Berekum Chelsea | 3-0 | LISCR Monrovia | |
| 19.02.2012 | LISCR Monrovia | 0-2 | Berekum Chelsea | |
Orlando Pirates 2-4 Recreativo Libolo *
| 03.03.2012 | Recreativo Libolo | 1-1 | Orlando Pirates | |
| 19.02.2012 | Orlando Pirates | 1-3 | Recreativo Libolo | |
Japan Actuel's 1-8 Power Dynamos *
| 04.03.2012 | Power Dynamos | 3-0 | Japan Actuel's | |
| 19.02.2012 | Japan Actuel's | 1-5 | Power Dynamos | |
*Brikama United 1-1 US Ouakam
| 03.03.2012 | US Ouakam | 0-1/p.1-3 | Brikama United | |
| 18.02.2012 | Brikama United | 0-1 | US Ouakam | |
Young Africans 1-2 Zamalek SC *
| 03.03.2012 | Zamalek SC | 1-0 | Young Africans | |
| 18.02.2012 | Young Africans | 1-1 | Zamalek SC | |