*Zamalek SC 2-2 Africa Sports
| 08.04.2012 | Africa Sports | 2-1 | Zamalek SC | |
| 25.03.2012 | Zamalek SC | 1-0 | Africa Sports | |
Ethiopian Coffee 0-3 Ahly Cairo *
| 08.04.2012 | Ahly Cairo | 3-0 | Ethiopian Coffee | |
| 25.03.2012 | Ethiopian Coffee | 0-0 | Ahly Cairo | |
Diplomates FC 8ème Arr. 1-8 Al Hilal Al Sudani *
| 06.04.2012 | Al Hilal Al Sudani | 5-1 | Diplomates FC 8ème Arr. | |
| 24.03.2012 | Diplomates FC 8ème Arr. | 0-3 | Al Hilal Al Sudani | |
*ASO Chlef 3-2 AS Vita Club
| 08.04.2012 | AS Vita Club | 2-3 | ASO Chlef | |
| 23.03.2012 | ASO Chlef | 0-0 | AS Vita Club | |
Brikama United 2-4 Esperance ST *
| 06.04.2012 | Esperance ST | 3-1 | Brikama United | |
| 24.03.2012 | Brikama United | 1-1 | Esperance ST | |
URA FC 0-4 Djoliba AC
| 08.04.2012 | Djoliba AC | 2-0 W.O. | URA FC | |
| 24.03.2012 | URA FC | 0-2 | Djoliba AC | |
Dolphins FC PH 2-2 Coton Sport *
| 08.04.2012 | Coton Sport | 1-0 | Dolphins FC PH | |
| 25.03.2012 | Dolphins FC PH | 2-1 | Coton Sport | |
APR FC 2-3 Étoile Sahel Sousse *
| 06.04.2012 | Étoile Sahel Sousse | 3-2 | APR FC | |
| 24.03.2012 | APR FC | 0-0 | Étoile Sahel Sousse | |
FC Platinum (ZIM) 2-5 Merreikh Al Sudan *
| 07.04.2012 | Merreikh Al Sudan | 3-0 | FC Platinum (ZIM) | |
| 24.03.2012 | FC Platinum (ZIM) | 2-2 | Merreikh Al Sudan | |
Horoya AC 1-4 Maghreb Fès *
| 08.04.2012 | Maghreb Fès | 3-0 | Horoya AC | |
| 25.03.2012 | Horoya AC | 1-1 | Maghreb Fès | |
JSM Béjaia 1-5 AFAD Djékanou *
| 07.04.2012 | AFAD Djékanou | 3-0 | JSM Béjaia | |
| 23.03.2012 | JSM Béjaia | 1-2 | AFAD Djékanou | |
Liga Muçulmana 2-3 Dynamos FC *
| 08.04.2012 | Dynamos FC | 1-0 | Liga Muçulmana | |
| 24.03.2012 | Liga Muçulmana | 2-2 | Dynamos FC | |
Power Dynamos 1-7 TP Mazembe *
| 08.04.2012 | TP Mazembe | 6-0 | Power Dynamos | |
| 24.03.2012 | Power Dynamos | 1-1 | TP Mazembe | |
Berekum Chelsea 5-3 Raja Casablanca
| 08.04.2012 | Raja Casablanca | 3-0 | Berekum Chelsea | |
| 25.03.2012 | Berekum Chelsea | 5-0 | Raja Casablanca | |
Tonnerre d'Abomey 2-5 Stade Malien
| 14.04.2012 | Stade Malien | 5-2 | Tonnerre d'Abomey | |
| 01.04.2012 | Tonnerre d'Abomey | 0-0 | Stade Malien | |
Recreativo Libolo 4-4 Sunshine Stars *
| 08.04.2012 | Sunshine Stars | 3-0 | Recreativo Libolo | |
| 25.03.2012 | Recreativo Libolo | 4-1 | Sunshine Stars | |