*KCCA FC 2-2 1º de Agosto
| 19.02.2017 | 1º de Agosto | 2-1 | KCCA FC | |
| 10.02.2017 | KCCA FC | 1-0 | 1º de Agosto | |
All Stars FC 1-5 Al Ahli Tripoli *
| 19.02.2017 | Al Ahli Tripoli | 2-0 | All Stars FC | |
| 12.02.2017 | All Stars FC | 1-3 | Al Ahli Tripoli | |
AS Real Bamako 0-4 Rivers United *
| 19.02.2017 | Rivers United | 4-0 | AS Real Bamako | |
| 11.02.2017 | AS Real Bamako | 0-0 | Rivers United | |
Royal Leopards 1-4 AS Vita Club *
| 19.02.2017 | AS Vita Club | 3-1 | Royal Leopards | |
| 11.02.2017 | Royal Leopards | 0-1 | AS Vita Club | |
*AS Tanda 4-3 ASFAN Niamey
| 18.02.2017 | ASFAN Niamey | 3-1 | AS Tanda | |
| 11.02.2017 | AS Tanda | 3-0 | ASFAN Niamey | |
*Coton Sport 7-2 Atlabara Juba
| 18.02.2017 | Atlabara Juba | 2-5 | Coton Sport | |
| 12.02.2017 | Coton Sport | 2-0 | Atlabara Juba | |
*BYC FC 1-1 Stade Malien
| 19.02.2017 | Stade Malien | 1-0/p.6-7 | BYC FC | |
| 12.02.2017 | BYC FC | 1-0 | Stade Malien | |
CD Elá Nguema 1-5 Al Merreikh SC *
| 18.02.2017 | Al Merreikh SC | 4-1 | CD Elá Nguema | |
| 12.02.2017 | CD Elá Nguema | 0-1 | Al Merreikh SC | |
*CF Mounana 3-0 Vital'O FC
| 19.02.2017 | Vital'O FC | 0-1 | CF Mounana | |
| 11.02.2017 | CF Mounana | 2-0 | Vital'O FC | |
*CNaPS Sport 4-4 Township Rollers
| 18.02.2017 | Township Rollers | 3-2 | CNaPS Sport | |
| 11.02.2017 | CNaPS Sport | 2-1 | Township Rollers | |
Côte d'Or FC 0-5 Saint George SA *
| 20.02.2017 | Saint George SA | 3-0 | Côte d'Or FC | |
| 11.02.2017 | Côte d'Or FC | 0-2 | Saint George SA | |
FC Johansen 1-4 FUS Rabat *
| 18.02.2017 | FUS Rabat | 3-0 | FC Johansen | |
| 11.02.2017 | FC Johansen | 1-1 | FUS Rabat | |
JS Saoura 1-1 Enugu Rangers *
| 19.02.2017 | Enugu Rangers | 0-0 | JS Saoura | |
| 10.02.2017 | JS Saoura | 1-1 | Enugu Rangers | |
Lioli FC 1-2 CAPS United FC *
| 19.02.2017 | CAPS United FC | 2-1 | Lioli FC | |
| 11.02.2017 | Lioli FC | 0-0 | CAPS United FC | |
*Rail Club Kadiogo 3-1 Diables Noirs
| 19.02.2017 | Diables Noirs | 1-0 | Rail Club Kadiogo | |
| 11.02.2017 | Rail Club Kadiogo | 3-0 | Diables Noirs | |
Sainte-Louisienne 3-4 Bidvest Wits *
| 18.02.2017 | Bidvest Wits | 3-1 | Sainte-Louisienne | |
| 11.02.2017 | Sainte-Louisienne | 2-1 | Bidvest Wits | |
*Gambia Ports A. 1-0 Séwé Sports
| 19.02.2017 | Séwé Sports | 0-0 | Gambia Ports A. | |
| 12.02.2017 | Gambia Ports A. | 1-0 | Séwé Sports | |
Tusker FC 2-3 AS Port-Louis 2000 *
| 19.02.2017 | AS Port-Louis 2000 | 2-1 | Tusker FC | |
| 11.02.2017 | Tusker FC | 1-1 | AS Port-Louis 2000 | |
*AC Léopard 2-2 UMS de Loum
| 19.02.2017 | UMS de Loum | 2-1 | AC Léopard | |
| 12.02.2017 | AC Léopard | 1-0 | UMS de Loum | |
Ngaya Club 2-6 Young Africans *
| 18.02.2017 | Young Africans | 1-1 | Ngaya Club | |
| 12.02.2017 | Ngaya Club | 1-5 | Young Africans | |
Zimamoto FC 3-4 Ferroviário da Beira *
| 19.02.2017 | Ferroviário da Beira | 3-1 | Zimamoto FC | |
| 11.02.2017 | Zimamoto FC | 2-1 | Ferroviário da Beira | |