1º de Agosto 4-4 AS Otôho *
| 05.12.2018 | AS Otôho | 2-0 | 1º de Agosto | |
| 28.11.2018 | 1º de Agosto | 4-2 | AS Otôho | |
Volcan Club 1-2 African Stars FC *
| 05.12.2018 | African Stars FC | 2-1 | Volcan Club | |
| 27.11.2018 | Volcan Club | 0-0 | African Stars FC | |
*Nasr Benghazi 9-3 Al Hilal Juba
| 04.12.2018 | Al Hilal Juba | 2-4 | Nasr Benghazi | |
| 27.11.2018 | Nasr Benghazi | 5-1 | Al Hilal Juba | |
APR FC 1-3 Club Africain Tunis *
| 04.12.2018 | Club Africain Tunis | 3-1 | APR FC | |
| 28.11.2018 | APR FC | 0-0 | Club Africain Tunis | |
*ASEC Mimosas 1-0 AS Mangasport
| 05.12.2018 | AS Mangasport | 0-0 | ASEC Mimosas | |
| 28.11.2018 | ASEC Mimosas | 1-0 | AS Mangasport | |
ASAS Djibouti Télécom 3-5 Jimma Aba Jifar *
| 04.12.2018 | Jimma Aba Jifar | 2-2 | ASAS Djibouti Télécom | |
| 27.11.2018 | ASAS Djibouti Télécom | 1-3 | Jimma Aba Jifar | |
*ASC Jaraaf 1-1 US Koroki
| 04.12.2018 | US Koroki | 1-0/p.2-4 | ASC Jaraaf | |
| 27.11.2018 | ASC Jaraaf | 1-0 | US Koroki | |
ASF Bobo 4-4 Coton Sport *
| 04.12.2018 | Coton Sport | 3-1/p.5-3 | ASF Bobo | |
| 27.11.2018 | ASF Bobo | 3-1 | Coton Sport | |
*CS Constantine 1-0 GAMTEL FC
| 05.12.2018 | GAMTEL FC | 0-1 | CS Constantine | |
| 27.11.2018 | CS Constantine | 0-0 | GAMTEL FC | |
FC Nouadhibou 2-3 Al Ahli Benghazi *
| 05.12.2018 | Al Ahli Benghazi | 2-0 | FC Nouadhibou | |
| 28.11.2018 | FC Nouadhibou | 2-1 | Al Ahli Benghazi | |
CNaPS Sport 1-2 FC Platinum (ZIM) *
| 05.12.2018 | FC Platinum (ZIM) | 1-0 | CNaPS Sport | |
| 28.11.2018 | CNaPS Sport | 1-1 | FC Platinum (ZIM) | |
*Gor Mahia 1-1 Nyasa Big Bullets
| 05.12.2018 | Nyasa Big Bullets | 1-0/p.3-4 | Gor Mahia | |
| 28.11.2018 | Gor Mahia | 1-0 | Nyasa Big Bullets | |
*Ittihad Tanger 1-0 Elect Sport FC
| 05.12.2018 | Elect Sport FC | 0-0 | Ittihad Tanger | |
| 27.11.2018 | Ittihad Tanger | 1-0 | Elect Sport FC | |
*Al Hilal Al Sudani 6-0 JKU FC
| 05.12.2018 | JKU FC | 0-2 | Al Hilal Al Sudani | |
| 27.11.2018 | Al Hilal Al Sudani | 4-0 | JKU FC | |
Le Messager Ngozi 1-3 Ismaily SC *
| 05.12.2018 | Ismaily SC | 2-1 | Le Messager Ngozi | |
| 28.11.2018 | Le Messager Ngozi | 0-1 | Ismaily SC | |
Leones Vegetarianos 1-7 Mamelodi Sundowns *
| 05.12.2018 | Mamelodi Sundowns | 5-1 | Leones Vegetarianos | |
| 28.11.2018 | Leones Vegetarianos | 0-2 | Mamelodi Sundowns | |
*Orlando Pirates 8-2 Light Stars
| 05.12.2018 | Light Stars | 1-3 | Orlando Pirates | |
| 28.11.2018 | Orlando Pirates | 5-1 | Light Stars | |
*Simba SC 8-1 Mbabane Swallows
| 04.12.2018 | Mbabane Swallows | 0-4 | Simba SC | |
| 28.11.2018 | Simba SC | 4-1 | Mbabane Swallows | |
SCAF Tocages Bangui 0-5 Stade Malien *
| 05.12.2018 | Stade Malien | 4-0 | SCAF Tocages Bangui | |
| 27.11.2018 | SCAF Tocages Bangui | 0-1 | Stade Malien | |
Township Rollers 2-2 Bantu FC *
| 04.12.2018 | Bantu FC | 1-1/p.4-2 | Township Rollers | |
| 27.11.2018 | Township Rollers | 1-1 | Bantu FC | |
UMS de Loum 1-2 Lobi Stars *
| 05.12.2018 | Lobi Stars | 2-0 | UMS de Loum | |
| 28.11.2018 | UMS de Loum | 1-0 | Lobi Stars | |
Al Merreikh SC 2-2 Vipers SC *
| 05.12.2018 | Vipers SC | 1-0 | Al Merreikh SC | |
| 28.11.2018 | Al Merreikh SC | 2-1 | Vipers SC | |
AS SONIDEB 1-5 ZESCO United *
| 04.12.2018 | ZESCO United | 3-0 | AS SONIDEB | |
| 27.11.2018 | AS SONIDEB | 1-2 | ZESCO United | |