Al Amal Atbara 1-2 CR Belouizdad *
| 07.05.2010 | CR Belouizdad | 2-0 | Al Amal Atbara | |
| 23.04.2010 | Al Amal Atbara | 1-0 | CR Belouizdad | |
ASFAN Niamey 1-0 DC Motema Pembe
| 08.05.2010 | DC Motema Pembe | 0-0 | ASFAN Niamey | |
| 24.04.2010 | ASFAN Niamey | 1-0 | DC Motema Pembe | |
Coton Sport 1-2 1º de Agosto *
| 08.05.2010 | 1º de Agosto | 0-0 | Coton Sport | |
| 24.04.2010 | Coton Sport | 1-2 | 1º de Agosto | |
Petrojet Suez 1-2 CS Sfaxien *
| 08.05.2010 | CS Sfaxien | 1-0 | Petrojet Suez | |
| 25.04.2010 | Petrojet Suez | 1-1 | CS Sfaxien | |
AS Vita Club 3-3 Enyimba *
| 09.05.2010 | Enyimba | 3-0/p.5-4 | AS Vita Club | |
| 25.04.2010 | AS Vita Club | 3-0 | Enyimba | |
*FUS Rabat 2-0 Stade Malien
| 08.05.2010 | Stade Malien | 0-0 | FUS Rabat | |
| 23.04.2010 | FUS Rabat | 2-0 | Stade Malien | |
Simba SC 3-6 Haras Al Hodoud *
| 08.05.2010 | Haras Al Hodoud | 5-1 | Simba SC | |
| 25.04.2010 | Simba SC | 2-1 | Haras Al Hodoud | |
Warri Wolves 2-3 CAPS United FC *
| 09.05.2010 | CAPS United FC | 2-0 | Warri Wolves | |
| 25.04.2010 | Warri Wolves | 2-1 | CAPS United FC | |