*1º de Agosto 2-1 AC Léopard
| 03.04.2011 | AC Léopard | 1-0 | 1º de Agosto | |
| 19.03.2011 | 1º de Agosto | 2-0 | AC Léopard | |
Al Nil Hasahesa 2-3 Missile FC *
| 02.04.2011 | Missile FC | 2-1 | Al Nil Hasahesa | |
| 18.03.2011 | Al Nil Hasahesa | 1-1 | Missile FC | |
Bidvest Wits 1-3 AS Adema *
| 03.04.2011 | AS Adema | 2-0 | Bidvest Wits | |
| 21.03.2011 | Bidvest Wits | 1-1 | AS Adema | |
Victors Kampala 1-2 DC Motema Pembe *
| 03.04.2011 | DC Motema Pembe | 1-0 | Victors Kampala | |
| 19.03.2011 | Victors Kampala | 1-1 | DC Motema Pembe | |
*Haras Al Hodoud 5-1 Dedebit FC
| 02.04.2011 | Dedebit FC | 1-1 | Haras Al Hodoud | |
| 20.03.2011 | Haras Al Hodoud | 4-0 | Dedebit FC | |
*Étoile Sahel Sousse 4-2 Ashanti Gold SC
| 03.04.2011 | Ashanti Gold SC | 2-1 | Étoile Sahel Sousse | |
| 20.03.2011 | Étoile Sahel Sousse | 3-0 | Ashanti Gold SC | |
*Kaduna United 2-1 Foullah Edifice
| 02.04.2011 | Foullah Edifice | 1-0 | Kaduna United | |
| 20.03.2011 | Kaduna United | 2-0 | Foullah Edifice | |
Ismaily SC 2-4 Sofapaka Nairobi *
| 02.04.2011 | Sofapaka Nairobi | 4-0 | Ismaily SC | |
| 18.03.2011 | Ismaily SC | 2-0 | Sofapaka Nairobi | |
*JS Kabylie 3-1 FC Tevragh-Zeina
| 02.04.2011 | FC Tevragh-Zeina | 1-2 | JS Kabylie | |
| 20.03.2011 | JS Kabylie | 1-0 | FC Tevragh-Zeina | |
| 02.04.2011 | Khartoum Al Watani | CANC | Nasr Benghazi | |
*Maghreb Fès 2-1 Sahel SC Niamey
| 03.04.2011 | Sahel SC Niamey | 1-2 | Maghreb Fès | |
| 19.03.2011 | Maghreb Fès | 0-0 | Sahel SC Niamey | |
*Saint Eloi Lupopo 3-0 Nchanga Rangers
| 02.04.2011 | Nchanga Rangers | 0-2 | Saint Eloi Lupopo | |
| 18.03.2011 | Saint Eloi Lupopo | 1-0 | Nchanga Rangers | |
Olympique Béja 2-3 Difaâ El Jadidi *
| 02.04.2011 | Difaâ El Jadidi | 3-0 | Olympique Béja | |
| 18.03.2011 | Olympique Béja | 2-0 | Difaâ El Jadidi | |
*Sunshine Stars 3-0 Tiko United
| 03.04.2011 | Tiko United | 0-1 | Sunshine Stars | |
| 20.03.2011 | Sunshine Stars | 2-0 | Tiko United | |
*FUS Rabat 3-2 Toure Kunda Footpro
| 02.04.2011 | Toure Kunda Footpro | 2-1 | FUS Rabat | |
| 19.03.2011 | FUS Rabat | 2-0 | Toure Kunda Footpro | |
US Forces Armées 0-0 Africa Sports
| 03.04.2011 | US Forces Armées | P-P | Africa Sports | |