African Stars FC 1-2 Raja Casablanca *
| 20.01.2019 | Raja Casablanca | 1-0 | African Stars FC | |
| 12.01.2019 | African Stars FC | 1-1 | Raja Casablanca | |
Al Ahli Benghazi 2-3 NA Hussein Dey *
| 20.01.2019 | NA Hussein Dey | 3-1 | Al Ahli Benghazi | |
| 11.01.2019 | Al Ahli Benghazi | 1-0 | NA Hussein Dey | |
*Al Hilal Al Sudani 3-1 Mukura Victory Sports
| 19.01.2019 | Mukura Victory Sports | 1-0 | Al Hilal Al Sudani | |
| 13.01.2019 | Al Hilal Al Sudani | 3-0 | Mukura Victory Sports | |
Coton Sport 3-5 Asante Kotoko *
| 20.01.2019 | Asante Kotoko | 2-1 | Coton Sport | |
| 13.01.2019 | Coton Sport | 2-3 | Asante Kotoko | |
ASC Jaraaf 3-5 Renaissance Berkane *
| 19.01.2019 | Renaissance Berkane | 5-1 | ASC Jaraaf | |
| 14.01.2019 | ASC Jaraaf | 2-0 | Renaissance Berkane | |
Bantu FC 2-4 Enugu Rangers *
| 20.01.2019 | Enugu Rangers | 2-1 | Bantu FC | |
| 13.01.2019 | Bantu FC | 1-2 | Enugu Rangers | |
*Nkana FC 3-0 FC San Pédro
| 20.01.2019 | FC San Pédro | 0-0 | Nkana FC | |
| 12.01.2019 | Nkana FC | 3-0 | FC San Pédro | |
*Gor Mahia 2-1 New Stars de Duala
| 20.01.2019 | New Stars de Duala | 0-0 | Gor Mahia | |
| 13.01.2019 | Gor Mahia | 2-1 | New Stars de Duala | |
Ittihad Tanger 1-3 Zamalek SC *
| 19.01.2019 | Zamalek SC | 3-1 | Ittihad Tanger | |
| 13.01.2019 | Ittihad Tanger | 0-0 | Zamalek SC | |
Jimma Aba Jifar 0-5 Hassania Agadir *
| 19.01.2019 | Hassania Agadir | 4-0 | Jimma Aba Jifar | |
| 13.01.2019 | Jimma Aba Jifar | 0-1 | Hassania Agadir | |
Nasr Benghazi 2-3 Salitas FC *
| 19.01.2019 | Salitas FC | 3-1 | Nasr Benghazi | |
| 13.01.2019 | Nasr Benghazi | 1-0 | Salitas FC | |
Stade Malien 2-3 Petro Atlético Luanda *
| 19.01.2019 | Petro Atlético Luanda | 2-1 | Stade Malien | |
| 12.01.2019 | Stade Malien | 1-1 | Petro Atlético Luanda | |
Vipers SC 0-3 CS Sfaxien *
| 20.01.2019 | CS Sfaxien | 3-0 | Vipers SC | |
| 12.01.2019 | Vipers SC | 0-0 | CS Sfaxien | |
*ZESCO United 5-2 Kaizer Chiefs
| 19.01.2019 | Kaizer Chiefs | 1-2 | ZESCO United | |
| 13.01.2019 | ZESCO United | 3-1 | Kaizer Chiefs | |