*Coton Sport 2-2 ASC Jaraaf
| 23.05.2021 | ASC Jaraaf | 2-1 | Coton Sport | |
| 16.05.2021 | Coton Sport | 1-0 | ASC Jaraaf | |
CS Sfaxien 1-2 JS Kabylie *
| 23.05.2021 | JS Kabylie | 1-1 | CS Sfaxien | |
| 16.05.2021 | CS Sfaxien | 0-1 | JS Kabylie | |
Orlando Pirates 1-5 Raja Casablanca *
| 23.05.2021 | Raja Casablanca | 4-0 | Orlando Pirates | |
| 16.05.2021 | Orlando Pirates | 1-1 | Raja Casablanca | |
*Pyramids FC 5-2 Enyimba
| 23.05.2021 | Enyimba | 1-1 | Pyramids FC | |
| 16.05.2021 | Pyramids FC | 4-1 | Enyimba | |