Guadalajara Chivas 1-4 Club América *
| 13.03.2025 | Club América | 4-0 | Guadalajara Chivas | |
| 06.03.2025 | Guadalajara Chivas | 1-0 | Club América | |
*Los Angeles FC 4-2 Columbus Crew
| 12.03.2025 | Columbus Crew | 2-1 | Los Angeles FC | |
| 05.03.2025 | Los Angeles FC | 3-0 | Columbus Crew | |
CS Herediano 2-4 Los Angeles Galaxy *
| 13.03.2025 | Los Angeles Galaxy | 4-1 | CS Herediano | |
| 06.03.2025 | CS Herediano | 1-0 | Los Angeles Galaxy | |
FC Cincinnati 2-4 Tigres UANL *
| 12.03.2025 | Tigres UANL | 3-1 | FC Cincinnati | |
| 05.03.2025 | FC Cincinnati | 1-1 | Tigres UANL | |
*Inter Miami CF 4-0 Cavalier FC
| 14.03.2025 | Cavalier FC | 0-2 | Inter Miami CF | |
| 07.03.2025 | Inter Miami CF | 2-0 | Cavalier FC | |
*UNAM Pumas 3-1 LD Alajuelense
| 14.03.2025 | LD Alajuelense | 1-1 | UNAM Pumas | |
| 05.03.2025 | UNAM Pumas | 2-0 | LD Alajuelense | |
Seattle Sounders 1-4 Cruz Azul *
| 12.03.2025 | Cruz Azul | 4-1 | Seattle Sounders | |
| 06.03.2025 | Seattle Sounders | 0-0 | Cruz Azul | |
*Vancouver WC 3-3 CF Monterrey
| 13.03.2025 | CF Monterrey | 2-2 | Vancouver WC | |
| 06.03.2025 | Vancouver WC | 1-1 | CF Monterrey | |