CD Jalapa 1-5 San Francisco FC
| 05.09.2008 | San Francisco FC | 5-0 | CD Jalapa | |
| 29.08.2008 | CD Jalapa | 1-0 | San Francisco FC | |
Isidro Metapán 3-4 CD Marathón
| 04.09.2008 | CD Marathón | 2-1 | Isidro Metapán | |
| 28.08.2008 | Isidro Metapán | 2-2 | CD Marathón | |
Tauro FC 3-1 Chivas USA
| 03.09.2008 | Chivas USA | 1-1 | Tauro FC | |
| 27.08.2008 | Tauro FC | 2-0 | Chivas USA | |
Cruz Azul 12-0 Hankook Verdes
| 04.09.2008 | Hankook Verdes | 0-6 | Cruz Azul | |
| 27.08.2008 | Cruz Azul | 6-0 | Hankook Verdes | |
LD Alajuelense 2-3 Puerto Rico Islanders
| 04.09.2008 | Puerto Rico Islanders | 2-1 | LD Alajuelense | |
| 28.08.2008 | LD Alajuelense | 1-1 | Puerto Rico Islanders | |
Montreal Impact 1-0 Real Estelí
| 03.09.2008 | Real Estelí | 0-0 | Montreal Impact | |
| 28.08.2008 | Montreal Impact | 1-0 | Real Estelí | |
Joe Public FC 6-1 New England Revs
| 03.09.2008 | New England Revs | 0-4 | Joe Public FC | |
| 27.08.2008 | Joe Public FC | 2-1 | New England Revs | |
UNAM Pumas 3-0 Harbour View
| 05.09.2008 | UNAM Pumas | 3-0 | Harbour View | |