Columbus Crew 1-4 Real Salt Lake *
| 02.03.2011 | Real Salt Lake | 4-1 | Columbus Crew | |
| 23.02.2011 | Columbus Crew | 0-0 | Real Salt Lake | |
*Cruz Azul 5-1 Santos Laguna
| 02.03.2011 | Santos Laguna | 1-3 | Cruz Azul | |
| 23.02.2011 | Cruz Azul | 2-0 | Santos Laguna | |
Deportivo Toluca 0-2 CF Monterrey *
| 03.03.2011 | CF Monterrey | 1-0 | Deportivo Toluca | |
| 24.02.2011 | Deportivo Toluca | 0-1 | CF Monterrey | |
*Saprissa 3-1 CD Olimpia
| 04.03.2011 | CD Olimpia | 1-2 | Saprissa | |
| 25.02.2011 | Saprissa | 1-0 | CD Olimpia | |