Los Angeles Galaxy 0-4 Santos Laguna *
| 02.03.2016 | Santos Laguna | 4-0 | Los Angeles Galaxy | |
| 25.02.2016 | Los Angeles Galaxy | 0-0 | Santos Laguna | |
*Querétaro FC 3-1 DC United
| 02.03.2016 | DC United | 1-1 | Querétaro FC | |
| 24.02.2016 | Querétaro FC | 2-0 | DC United | |
Seattle Sounders 3-5 Club América *
| 03.03.2016 | Club América | 3-1 | Seattle Sounders | |
| 24.02.2016 | Seattle Sounders | 2-2 | Club América | |
*Tigres UANL 3-1 Real Salt Lake
| 03.03.2016 | Real Salt Lake | 1-1 | Tigres UANL | |
| 25.02.2016 | Tigres UANL | 2-0 | Real Salt Lake | |