*Club América 3-1 Atlanta United
| 17.12.2020 | Atlanta United | 1-0 | Club América | |
| 12.03.2020 | Club América | 3-0 | Atlanta United | |
Montreal Impact 2-2 CD Olimpia *
| 16.12.2020 | CD Olimpia | 0-1 | Montreal Impact | |
| 11.03.2020 | Montreal Impact | 1-2 | CD Olimpia | |
*Los Angeles FC 2-1 Cruz Azul
| 17.12.2020 | Los Angeles FC | 2-1 | Cruz Azul | |
New York City FC 0-5 Tigres UANL *
| 16.12.2020 | Tigres UANL | 4-0 | New York City FC | |
| 12.03.2020 | New York City FC | 0-1 | Tigres UANL | |