*Club Tijuana 2-1 Palmeiras/SP
| 15.05.2013 | Palmeiras/SP | 1-2 | Club Tijuana | |
| 01.05.2013 | Club Tijuana | 0-0 | Palmeiras/SP | |
*Boca Juniors 2-1 Corinthians/SP
| 16.05.2013 | Corinthians/SP | 1-1 | Boca Juniors | |
| 02.05.2013 | Boca Juniors | 1-0 | Corinthians/SP | |
CS Emelec 2-3 Fluminense/RJ *
| 09.05.2013 | Fluminense/RJ | 2-0 | CS Emelec | |
| 03.05.2013 | CS Emelec | 2-1 | Fluminense/RJ | |
Grêmio/RS 2-2 Club Santa Fe *
| 17.05.2013 | Club Santa Fe | 1-0 | Grêmio/RS | |
| 02.05.2013 | Grêmio/RS | 2-1 | Club Santa Fe | |
*Real Garcilaso 1-1 Nacional (URU)
| 10.05.2013 | Nacional (URU) | 1-0/p.1-4 | Real Garcilaso | |
| 26.04.2013 | Real Garcilaso | 1-0 | Nacional (URU) | |
CA Tigre 2-3 Olimpia Asunción *
| 17.05.2013 | Olimpia Asunción | 2-0 | CA Tigre | |
| 01.05.2013 | CA Tigre | 2-1 | Olimpia Asunción | |
São Paulo/SP 2-6 Atlético Mineiro/MG *
| 09.05.2013 | Atlético Mineiro/MG | 4-1 | São Paulo/SP | |
| 03.05.2013 | São Paulo/SP | 1-2 | Atlético Mineiro/MG | |
*Newell's Old Boys 2-2 Vélez Sársfield
| 16.05.2013 | Vélez Sársfield | 1-2 | Newell's Old Boys | |
| 25.04.2013 | Newell's Old Boys | 0-1 | Vélez Sársfield | |