Deportivo La Guaira 0-1 Atlético Nacional *
| 15.02.2019 | Atlético Nacional | 0-0 | Deportivo La Guaira | |
| 08.02.2019 | Deportivo La Guaira | 0-1 | Atlético Nacional | |
Delfin SC 1-1 Caracas FC *
| 14.02.2019 | Caracas FC | 0-0 | Delfin SC | |
| 06.02.2019 | Delfin SC | 1-1 | Caracas FC | |
*CD Palestino 2-2 Independiente Medellín
| 13.02.2019 | Independiente Medellín | 1-1/p.1-4 | CD Palestino | |
| 07.02.2019 | CD Palestino | 1-1 | Independiente Medellín | |
The Strongest 2-6 Club Libertad *
| 13.02.2019 | Club Libertad | 5-1 | The Strongest | |
| 06.02.2019 | The Strongest | 1-1 | Club Libertad | |
Danubio FC 4-5 Atlético Mineiro/MG *
| 12.02.2019 | Atlético Mineiro/MG | 3-2 | Danubio FC | |
| 05.02.2019 | Danubio FC | 2-2 | Atlético Mineiro/MG | |
*Defensor Sporting 3-1 Barcelona SC
| 13.02.2019 | Barcelona SC | 1-0 | Defensor Sporting | |
| 06.02.2019 | Defensor Sporting | 3-0 W.O. | Barcelona SC | |
*FBC Melgar 1-0 Univ de Chile
| 13.02.2019 | Univ de Chile | 0-0 | FBC Melgar | |
| 06.02.2019 | FBC Melgar | 1-0 | Univ de Chile | |
*Talleres Córdoba 2-0 São Paulo/SP
| 14.02.2019 | São Paulo/SP | 0-0 | Talleres Córdoba | |
| 07.02.2019 | Talleres Córdoba | 2-0 | São Paulo/SP | |