*Club América 7-4 Atlético Nacional
| 06.10.2005 | Atlético Nacional | 1-4 | Club América | |
| 22.09.2005 | Club América | 3-3 | Atlético Nacional | |
Cerro Porteño 3-7 Boca Juniors *
| 30.09.2005 | Boca Juniors | 5-1 | Cerro Porteño | |
| 22.09.2005 | Cerro Porteño | 2-2 | Boca Juniors | |
*Fluminense/RJ 3-1 CA Banfield
| 29.09.2005 | CA Banfield | 0-0 | Fluminense/RJ | |
| 15.09.2005 | Fluminense/RJ | 3-1 | CA Banfield | |
*Corinthians/SP 1-1 River Plate
| 29.09.2005 | River Plate | 1-1 | Corinthians/SP | |
| 15.09.2005 | Corinthians/SP | 0-0 | River Plate | |
DC United 3-4 Universidad Católica *
| 23.09.2005 | Universidad Católica | 3-2 | DC United | |
| 14.09.2005 | DC United | 1-1 | Universidad Católica | |
Rosario Central 1-2 Internacional/RS *
| 30.09.2005 | Internacional/RS | 1-1 | Rosario Central | |
| 16.09.2005 | Rosario Central | 0-1 | Internacional/RS | |
*UNAM Pumas 4-3 The Strongest
| 06.10.2005 | The Strongest | 2-1 | UNAM Pumas | |
| 21.09.2005 | UNAM Pumas | 3-1 | The Strongest | |
*Vélez Sársfield 3-2 Cruzeiro/MG
| 29.09.2005 | Cruzeiro/MG | 2-1 | Vélez Sársfield | |
| 15.09.2005 | Vélez Sársfield | 2-0 | Cruzeiro/MG | |