*Cerro Porteño 5-2 Botafogo/RJ
| 05.11.2009 | Botafogo/RJ | 1-3 | Cerro Porteño | |
| 22.10.2009 | Cerro Porteño | 2-1 | Botafogo/RJ | |
*Fluminense/RJ 3-2 Univ de Chile
| 06.11.2009 | Univ de Chile | 0-1 | Fluminense/RJ | |
| 23.10.2009 | Fluminense/RJ | 2-2 | Univ de Chile | |
*River Plate (URU) 1-1 San Lorenzo
| 04.11.2009 | San Lorenzo | 0-1/p.6-7 | River Plate (URU) | |
| 21.10.2009 | River Plate (URU) | 0-1 | San Lorenzo | |
Vélez Sársfield 2-3 LDU Quito *
| 06.11.2009 | LDU Quito | 2-1 | Vélez Sársfield | |
| 21.10.2009 | Vélez Sársfield | 1-1 | LDU Quito | |