Alianza Atlético 3-6 Fluminense/RJ *
| 02.10.2009 | Fluminense/RJ | 4-1 | Alianza Atlético | |
| 24.09.2009 | Alianza Atlético | 2-2 | Fluminense/RJ | |
*Cerro Porteño 3-3 Goiás/GO
| 02.10.2009 | Goiás/GO | 3-1 | Cerro Porteño | |
| 25.09.2009 | Cerro Porteño | 2-0 | Goiás/GO | |
Botafogo/RJ 3-2 CS Emelec
| 01.10.2009 | CS Emelec | 2-1 | Botafogo/RJ | |
| 24.09.2009 | Botafogo/RJ | 2-0 | CS Emelec | |
Internacional/RS 1-2 Univ de Chile
| 01.10.2009 | Univ de Chile | 1-0 | Internacional/RS | |
| 24.09.2009 | Internacional/RS | 1-1 | Univ de Chile | |
*San Lorenzo 5-0 Cienciano
| 01.10.2009 | Cienciano | 0-2 | San Lorenzo | |
| 25.09.2009 | San Lorenzo | 3-0 | Cienciano | |
*Vélez Sársfield 5-4 Unión Española
| 02.10.2009 | Unión Española | 2-2 | Vélez Sársfield | |
| 24.09.2009 | Vélez Sársfield | 3-2 | Unión Española | |
*River Plate (URU) 5-2 Vitória/BA
| 01.10.2009 | Vitória/BA | 1-1 | River Plate (URU) | |
| 23.09.2009 | River Plate (URU) | 4-1 | Vitória/BA | |