Chapecoense/SC 0-4 Flamengo/RJ *
| 21.09.2017 | Flamengo/RJ | 4-0 | Chapecoense/SC | |
| 14.09.2017 | Chapecoense/SC | 0-0 | Flamengo/RJ | |
*Club Libertad 2-1 Ind. Santa Fe
| 15.09.2017 | Ind. Santa Fe | 1-1 | Club Libertad | |
| 25.08.2017 | Club Libertad | 1-0 | Ind. Santa Fe | |
Corinthians/SP 1-1 Racing Club *
| 21.09.2017 | Racing Club | 0-0 | Corinthians/SP | |
| 14.09.2017 | Corinthians/SP | 1-1 | Racing Club | |
Atlético Tucumán 1-2 Independiente *
| 13.09.2017 | Independiente | 2-0 | Atlético Tucumán | |
| 23.08.2017 | Atlético Tucumán | 1-0 | Independiente | |
Cerro Porteño 1-3 Junior Barranquilla *
| 20.09.2017 | Junior Barranquilla | 3-1 | Cerro Porteño | |
| 13.09.2017 | Cerro Porteño | 0-0 | Junior Barranquilla | |
*Fluminense/RJ 2-2 LDU Quito
| 22.09.2017 | LDU Quito | 2-1 | Fluminense/RJ | |
| 15.09.2017 | Fluminense/RJ | 1-0 | LDU Quito | |
*Nacional Asunción 2-0 Estudiantes La Plata
| 20.09.2017 | Estudiantes La Plata | 0-1 | Nacional Asunción | |
| 24.08.2017 | Nacional Asunción | 1-0 | Estudiantes La Plata | |
*Sport Recife/PE 3-2 Ponte Preta/SP
| 21.09.2017 | Ponte Preta/SP | 1-0 | Sport Recife/PE | |
| 14.09.2017 | Sport Recife/PE | 3-1 | Ponte Preta/SP | |