FC Porto 2-6 Arsenal FC *
| 09.03.2010 | Arsenal FC | 5-0 | FC Porto | |
| 17.02.2010 | FC Porto | 2-1 | Arsenal FC | |
*Bayern München 4-4 Fiorentina
| 09.03.2010 | Fiorentina | 3-2 | Bayern München | |
| 17.02.2010 | Bayern München | 2-1 | Fiorentina | |
*Inter Milan 3-1 Chelsea FC
| 16.03.2010 | Chelsea FC | 0-1 | Inter Milan | |
| 24.02.2010 | Inter Milan | 2-1 | Chelsea FC | |
VfB Stuttgart 1-5 FC Barcelona *
| 17.03.2010 | FC Barcelona | 4-0 | VfB Stuttgart | |
| 23.02.2010 | VfB Stuttgart | 1-1 | FC Barcelona | |
Olympiakos Pireus 1-3 Girondins Bordeaux *
| 17.03.2010 | Girondins Bordeaux | 2-1 | Olympiakos Pireus | |
| 23.02.2010 | Olympiakos Pireus | 0-1 | Girondins Bordeaux | |
*Lyon 2-1 Real Madrid
| 10.03.2010 | Real Madrid | 1-1 | Lyon | |
| 16.02.2010 | Lyon | 1-0 | Real Madrid | |
AC Milan 2-7 Manchester United *
| 10.03.2010 | Manchester United | 4-0 | AC Milan | |
| 16.02.2010 | AC Milan | 2-3 | Manchester United | |
*CSKA Moscow 3-2 Sevilla FC
| 16.03.2010 | Sevilla FC | 1-2 | CSKA Moscow | |
| 24.02.2010 | CSKA Moscow | 1-1 | Sevilla FC | |