Atalanta Bergamo 1-4 Real Madrid *
| 16.03.2021 | Real Madrid | 3-1 | Atalanta Bergamo | |
| 24.02.2021 | Atalanta Bergamo | 0-1 | Real Madrid | |
Lazio 2-6 Bayern München *
| 17.03.2021 | Bayern München | 2-1 | Lazio | |
| 23.02.2021 | Lazio | 1-4 | Bayern München | |
Atlético Madrid 0-3 Chelsea FC *
| 17.03.2021 | Chelsea FC | 2-0 | Atlético Madrid | |
| 23.02.2021 | Atlético Madrid | 0-1 | Chelsea FC | |
*FC Porto 4-4 Juventus FC
| 09.03.2021 | Juventus FC | 3-2 AET | FC Porto | |
| 17.02.2021 | FC Porto | 2-1 | Juventus FC | |
RB Leipzig 0-4 Liverpool *
| 10.03.2021 | Liverpool | 2-0 | RB Leipzig | |
| 16.02.2021 | RB Leipzig | 0-2 | Liverpool | |
Mönchengladbach 0-4 Manchester City *
| 16.03.2021 | Manchester City | 2-0 | Mönchengladbach | |
| 24.02.2021 | Mönchengladbach | 0-2 | Manchester City | |
FC Barcelona 2-5 Paris St. Germain *
| 10.03.2021 | Paris St. Germain | 1-1 | FC Barcelona | |
| 16.02.2021 | FC Barcelona | 1-4 | Paris St. Germain | |
Sevilla FC 4-5 Borussia Dortmund *
| 09.03.2021 | Borussia Dortmund | 2-2 | Sevilla FC | |
| 17.02.2021 | Sevilla FC | 2-3 | Borussia Dortmund | |