Connah's Quay 2-3 Alashkert Martuni *
| 14.07.2021 | Alashkert Martuni | 1-0 AET | Connah's Quay | |
| 07.07.2021 | Connah's Quay | 2-2 | Alashkert Martuni | |
*CFR Cluj 4-3 Borac Banja Luka
| 13.07.2021 | Borac Banja Luka | 2-1 AET | CFR Cluj | |
| 06.07.2021 | CFR Cluj | 3-1 | Borac Banja Luka | |
CS Fola Esch 2-7 Lincoln Red Imps *
| 13.07.2021 | Lincoln Red Imps | 5-0 | CS Fola Esch | |
| 06.07.2021 | CS Fola Esch | 2-2 | Lincoln Red Imps | |
*Dinamo Zagreb 5-2 Valur Reykjavik
| 13.07.2021 | Valur Reykjavik | 0-2 | Dinamo Zagreb | |
| 07.07.2021 | Dinamo Zagreb | 3-2 | Valur Reykjavik | |
*Ferencvaros TC 6-1 KF Prishtina
| 13.07.2021 | KF Prishtina | 1-3 | Ferencvaros TC | |
| 06.07.2021 | Ferencvaros TC | 3-0 | KF Prishtina | |
*Flora Tallinn 5-0 Hibernians Paola
| 13.07.2021 | Hibernians Paola | 0-3 | Flora Tallinn | |
| 06.07.2021 | Flora Tallinn | 2-0 | Hibernians Paola | |
*HJK Helsinki 7-1 FK Buducnost
| 13.07.2021 | FK Buducnost | 0-4 | HJK Helsinki | |
| 06.07.2021 | HJK Helsinki | 3-1 | FK Buducnost | |
FK Bodo/Glimt 2-5 Legia Warszawa *
| 14.07.2021 | Legia Warszawa | 2-0 | FK Bodo/Glimt | |
| 07.07.2021 | FK Bodo/Glimt | 2-3 | Legia Warszawa | |
*VMFD Zalgiris 5-2 Linfield Belfast
| 13.07.2021 | Linfield Belfast | 1-2 | VMFD Zalgiris | |
| 06.07.2021 | VMFD Zalgiris | 3-1 | Linfield Belfast | |
*Ludogorets 2-0 Shakhter Soligorsk
| 13.07.2021 | Shakhter Soligorsk | 0-1 | Ludogorets | |
| 07.07.2021 | Ludogorets | 1-0 | Shakhter Soligorsk | |
Maccabi Haifa 1-3 Kairat Almaty *
| 14.07.2021 | Kairat Almaty | 2-0 | Maccabi Haifa | |
| 07.07.2021 | Maccabi Haifa | 1-1 | Kairat Almaty | |
Shkendija'79 0-6 Mura *
| 13.07.2021 | Mura | 5-0 | Shkendija'79 | |
| 06.07.2021 | Shkendija'79 | 0-1 | Mura | |
Dinamo Tbilisi 2-4 Neftchi Baku *
| 14.07.2021 | Neftchi Baku | 2-1 | Dinamo Tbilisi | |
| 07.07.2021 | Dinamo Tbilisi | 1-2 | Neftchi Baku | |
KF Teuta Durres 0-5 Sheriff Tiraspol *
| 13.07.2021 | Sheriff Tiraspol | 1-0 | KF Teuta Durres | |
| 07.07.2021 | KF Teuta Durres | 0-4 | Sheriff Tiraspol | |
*Slovan Bratislava 3-2 Shamrock Rovers
| 13.07.2021 | Shamrock Rovers | 2-1 | Slovan Bratislava | |
| 07.07.2021 | Slovan Bratislava | 2-0 | Shamrock Rovers | |