Sparta Praha 1-5 AS Monaco *
| 10.08.2021 | AS Monaco | 3-1 | Sparta Praha | |
| 03.08.2021 | Sparta Praha | 0-2 | AS Monaco | |
*PSV Eindhoven 4-0 FC Midtjylland
| 10.08.2021 | FC Midtjylland | 0-1 | PSV Eindhoven | |
| 03.08.2021 | PSV Eindhoven | 3-0 | FC Midtjylland | |
Racing Genk 2-4 Shakhtar Donetsk *
| 10.08.2021 | Shakhtar Donetsk | 2-1 | Racing Genk | |
| 03.08.2021 | Racing Genk | 1-2 | Shakhtar Donetsk | |
Spartak Moscow 0-4 SL Benfica *
| 10.08.2021 | SL Benfica | 2-0 | Spartak Moscow | |
| 04.08.2021 | Spartak Moscow | 0-2 | SL Benfica | |