*Qarabag FK 5-4 FC Zürich
| 27.07.2022 | FC Zürich | 2-2 AET | Qarabag FK | |
| 19.07.2022 | Qarabag FK | 3-2 | FC Zürich | |
*Ferencvaros TC 5-3 Slovan Bratislava
| 27.07.2022 | Slovan Bratislava | 1-4 | Ferencvaros TC | |
| 20.07.2022 | Ferencvaros TC | 1-2 | Slovan Bratislava | |
Linfield Belfast 1-8 FK Bodo/Glimt *
| 27.07.2022 | FK Bodo/Glimt | 8-0 | Linfield Belfast | |
| 19.07.2022 | Linfield Belfast | 1-0 | FK Bodo/Glimt | |
*VMFD Zalgiris 3-0 Malmö FF
| 27.07.2022 | Malmö FF | 0-2 | VMFD Zalgiris | |
| 19.07.2022 | VMFD Zalgiris | 1-0 | Malmö FF | |
*Maccabi Haifa 5-1 Olympiakos Pireus
| 27.07.2022 | Olympiakos Pireus | 0-4 | Maccabi Haifa | |
| 20.07.2022 | Maccabi Haifa | 1-1 | Olympiakos Pireus | |
*Pyunik FC 4-2 F91 Dudelange
| 26.07.2022 | F91 Dudelange | 1-4 | Pyunik FC | |
| 19.07.2022 | Pyunik FC | 0-1 | F91 Dudelange | |
*Ludogorets 4-2 Shamrock Rovers
| 26.07.2022 | Shamrock Rovers | 2-1 | Ludogorets | |
| 19.07.2022 | Ludogorets | 3-0 | Shamrock Rovers | |
Maribor 0-1 Sheriff Tiraspol *
| 26.07.2022 | Sheriff Tiraspol | 1-0 | Maribor | |
| 20.07.2022 | Maribor | 0-0 | Sheriff Tiraspol | |
*Dinamo Zagreb 3-2 Shkupi
| 26.07.2022 | Shkupi | 0-1 | Dinamo Zagreb | |
| 19.07.2022 | Dinamo Zagreb | 2-2 | Shkupi | |
HJK Helsinki 1-7 Viktoria Plzen *
| 26.07.2022 | Viktoria Plzen | 5-0 | HJK Helsinki | |
| 20.07.2022 | HJK Helsinki | 1-2 | Viktoria Plzen | |