*Velez Mostar 4-2 Coleraine FC
| 15.07.2021 | Coleraine FC | 1-2 | Velez Mostar | |
| 08.07.2021 | Velez Mostar | 2-1 | Coleraine FC | |
*MSK Zilina 6-3 Dila Gori
| 15.07.2021 | Dila Gori | 2-1 | MSK Zilina | |
| 08.07.2021 | MSK Zilina | 5-1 | Dila Gori | |
*Domžale 2-1 Swift Hesperange
| 15.07.2021 | Swift Hesperange | 1-1 | Domžale | |
| 08.07.2021 | Domžale | 1-0 | Swift Hesperange | |
*Drita FC 3-1 Decic Tuzi
| 15.07.2021 | Decic Tuzi | 0-1 | Drita FC | |
| 08.07.2021 | Drita FC | 2-1 | Decic Tuzi | |
*Dundalk FC 5-0 Newtown AFC
| 13.07.2021 | Newtown AFC | 0-1 | Dundalk FC | |
| 08.07.2021 | Dundalk FC | 4-0 | Newtown AFC | |
Europa FC 0-2 FK Kauno Zalgiris *
| 15.07.2021 | FK Kauno Zalgiris | 2-0 | Europa FC | |
| 08.07.2021 | Europa FC | 0-0 | FK Kauno Zalgiris | |
*FC Honka Espoo 3-1 NSI Runavik
| 15.07.2021 | NSI Runavik | 1-3 | FC Honka Espoo | |
| 08.07.2021 | FC Honka Espoo | 0-0 | NSI Runavik | |
*FK Liepaja 5-2 FC Struga
| 15.07.2021 | FC Struga | 1-4 | FK Liepaja | |
| 08.07.2021 | FK Liepaja | 1-1 | FC Struga | |
Fehervar FC 1-3 Ararat Yerevan *
| 15.07.2021 | Ararat Yerevan | 2-0 | Fehervar FC | |
| 08.07.2021 | Fehervar FC | 1-1 | Ararat Yerevan | |
*FH Hafnarfjordur 3-1 Sligo Rovers
| 15.07.2021 | Sligo Rovers | 1-2 | FH Hafnarfjordur | |
| 08.07.2021 | FH Hafnarfjordur | 1-0 | Sligo Rovers | |
*FK RFS 6-5 KI Klaksvik
| 15.07.2021 | KI Klaksvik | 2-4 AET | FK RFS | |
| 08.07.2021 | FK RFS | 2-3 | KI Klaksvik | |
*FC Milsami 1-0 FK Sarajevo
| 15.07.2021 | FK Sarajevo | 0-1 | FC Milsami | |
| 08.07.2021 | FC Milsami | 0-0 | FK Sarajevo | |
*FK Suduva 2-1 Valmieras FK
| 15.07.2021 | Valmieras FK | 0-0 | FK Suduva | |
| 08.07.2021 | FK Suduva | 2-1 | Valmieras FK | |
Glentoran Belfast 1-3 The New Saints *
| 15.07.2021 | The New Saints | 2-0 | Glentoran Belfast | |
| 08.07.2021 | Glentoran Belfast | 1-1 | The New Saints | |
Inter Turku 1-3 Puskás Akadémia *
| 15.07.2021 | Puskás Akadémia | 2-0 | Inter Turku | |
| 08.07.2021 | Inter Turku | 1-1 | Puskás Akadémia | |
FC Noah 1-5 KuPS Kuopio *
| 15.07.2021 | KuPS Kuopio | 5-0 | FC Noah | |
| 08.07.2021 | FC Noah | 1-0 | KuPS Kuopio | |
Mons Calpe SC 1-5 FC Santa Coloma *
| 15.07.2021 | FC Santa Coloma | 4-0 | Mons Calpe SC | |
| 06.07.2021 | Mons Calpe SC | 1-1 | FC Santa Coloma | |
Mosta FC 3-4 Spartak Trnava *
| 15.07.2021 | Spartak Trnava | 2-0 | Mosta FC | |
| 06.07.2021 | Mosta FC | 3-2 | Spartak Trnava | |
Paide Linnameeskond 1-4 Śląsk Wrocław *
| 15.07.2021 | Śląsk Wrocław | 2-0 | Paide Linnameeskond | |
| 08.07.2021 | Paide Linnameeskond | 1-2 | Śląsk Wrocław | |
*Partizani Tirana 8-4 Sfîntul Gheorghe
| 15.07.2021 | Sfîntul Gheorghe | 2-3 | Partizani Tirana | |
| 08.07.2021 | Partizani Tirana | 5-2 | Sfîntul Gheorghe | |
RFCU Luxemburg 2-5 Breidablik *
| 15.07.2021 | Breidablik | 2-0 | RFCU Luxemburg | |
| 08.07.2021 | RFCU Luxemburg | 2-3 | Breidablik | |
Sileks Kratovo 1-2 Petrocub Hîncești *
| 15.07.2021 | Petrocub Hîncești | 1-0 | Sileks Kratovo | |
| 08.07.2021 | Sileks Kratovo | 1-1 | Petrocub Hîncești | |
Siroki Brijeg 3-4 Vllaznia Shkodër *
| 15.07.2021 | Vllaznia Shkodër | 3-0 | Siroki Brijeg | |
| 08.07.2021 | Siroki Brijeg | 3-1 | Vllaznia Shkodër | |
*Birkirkara FC 2-1 SP La Fiorita
| 15.07.2021 | SP La Fiorita | 1-1 | Birkirkara FC | |
| 08.07.2021 | Birkirkara FC | 1-0 | SP La Fiorita | |
SP Tre Penne 0-7 Dinamo Batumi *
| 15.07.2021 | Dinamo Batumi | 3-0 | SP Tre Penne | |
| 08.07.2021 | SP Tre Penne | 0-4 | Dinamo Batumi | |
*Levadia Tallinn 4-2 St Joseph's (GIB)
| 15.07.2021 | St Joseph's (GIB) | 1-1 | Levadia Tallinn | |
| 08.07.2021 | Levadia Tallinn | 3-1 | St Joseph's (GIB) | |
Stjarnan FC 1-4 Bohemians FC *
| 15.07.2021 | Bohemians FC | 3-0 | Stjarnan FC | |
| 08.07.2021 | Stjarnan FC | 1-1 | Bohemians FC | |
*Sutjeska Niksic 2-1 Gagra Tbilisi
| 15.07.2021 | Gagra Tbilisi | 1-1 | Sutjeska Niksic | |
| 08.07.2021 | Sutjeska Niksic | 1-0 | Gagra Tbilisi | |
UE Sant Julià 1-1 Gzira United *
| 15.07.2021 | Gzira United | 1-1/p.5-3 | UE Sant Julià | |
| 08.07.2021 | UE Sant Julià | 0-0 | Gzira United | |