Breidablik 3-5 Aberdeen FC *
| 12.08.2021 | Aberdeen FC | 2-1 | Breidablik | |
| 05.08.2021 | Breidablik | 2-3 | Aberdeen FC | |
PFC Sochi 3-3 FK Partizan *
| 12.08.2021 | FK Partizan | 2-2/p.4-2 | PFC Sochi | |
| 05.08.2021 | PFC Sochi | 1-1 | FK Partizan | |
Cukaricki Belgrade 4-6 Hammarby IF *
| 12.08.2021 | Hammarby IF | 5-1 | Cukaricki Belgrade | |
| 05.08.2021 | Cukaricki Belgrade | 3-1 | Hammarby IF | |
Hibernian FC 2-5 HNK Rijeka *
| 12.08.2021 | HNK Rijeka | 4-1 | Hibernian FC | |
| 05.08.2021 | Hibernian FC | 1-1 | HNK Rijeka | |
*IF Elfsborg 5-2 Velez Mostar
| 12.08.2021 | Velez Mostar | 1-4 | IF Elfsborg | |
| 05.08.2021 | IF Elfsborg | 1-1 | Velez Mostar | |
KF Laci 1-5 Anderlecht *
| 12.08.2021 | Anderlecht | 2-1 | KF Laci | |
| 05.08.2021 | KF Laci | 0-3 | Anderlecht | |
Kolos Kovalivka 0-0 Shakhtyor Karagandy *
| 10.08.2021 | Shakhtyor Karagandy | 0-0/p.3-1 | Kolos Kovalivka | |
| 05.08.2021 | Kolos Kovalivka | 0-0 | Shakhtyor Karagandy | |
*KuPS Kuopio 5-4 FC Astana
| 12.08.2021 | FC Astana | 3-4 | KuPS Kuopio | |
| 05.08.2021 | KuPS Kuopio | 1-1 | FC Astana | |
*Paços de Ferreira 4-1 Larne FC
| 12.08.2021 | Larne FC | 1-0 | Paços de Ferreira | |
| 05.08.2021 | Paços de Ferreira | 4-0 | Larne FC | |
FK Vojvodina 1-7 LASK Linz *
| 12.08.2021 | LASK Linz | 6-1 | FK Vojvodina | |
| 05.08.2021 | FK Vojvodina | 0-1 | LASK Linz | |
Lokomotiv Plovdiv 3-5 FC København *
| 12.08.2021 | FC København | 4-2 | Lokomotiv Plovdiv | |
| 05.08.2021 | Lokomotiv Plovdiv | 1-1 | FC København | |
Spartak Trnava 0-1 Maccabi Tel Aviv *
| 12.08.2021 | Maccabi Tel Aviv | 1-0 | Spartak Trnava | |
| 05.08.2021 | Spartak Trnava | 0-0 | Maccabi Tel Aviv | |
*Trabzonspor 4-4 Molde FK
| 12.08.2021 | Molde FK | 1-1/p.3-4 | Trabzonspor | |
| 05.08.2021 | Trabzonspor | 3-3 | Molde FK | |
*CSKA Sofia 5-3 NK Osijek
| 12.08.2021 | NK Osijek | 1-1 | CSKA Sofia | |
| 05.08.2021 | CSKA Sofia | 4-2 | NK Osijek | |
*CD Santa Clara 3-0 Olimpija Ljubljana
| 12.08.2021 | Olimpija Ljubljana | 0-1 | CD Santa Clara | |
| 05.08.2021 | CD Santa Clara | 2-0 | Olimpija Ljubljana | |
Bohemians FC 2-3 PAOK Salonica *
| 12.08.2021 | PAOK Salonica | 2-0 | Bohemians FC | |
| 03.08.2021 | Bohemians FC | 2-1 | PAOK Salonica | |
AEL Limassol 1-2 Qarabag FK *
| 12.08.2021 | Qarabag FK | 1-0 | AEL Limassol | |
| 05.08.2021 | AEL Limassol | 1-1 | Qarabag FK | |
*Raków 1-0 Rubin Kazan
| 12.08.2021 | Rubin Kazan | 0-1 AET | Raków | |
| 05.08.2021 | Raków | 0-0 | Rubin Kazan | |
*Rosenborg BK 8-2 Domžale
| 10.08.2021 | Domžale | 1-2 | Rosenborg BK | |
| 05.08.2021 | Rosenborg BK | 6-1 | Domžale | |
Dinamo Batumi 2-3 Sivasspor *
| 12.08.2021 | Sivasspor | 1-1 AET | Dinamo Batumi | |
| 05.08.2021 | Dinamo Batumi | 1-2 | Sivasspor | |
Śląsk Wrocław 2-5 Hapoel Be'er Sheva *
| 12.08.2021 | Hapoel Be'er Sheva | 4-0 | Śląsk Wrocław | |
| 05.08.2021 | Śląsk Wrocław | 2-1 | Hapoel Be'er Sheva | |
The New Saints 5-5 Viktoria Plzen *
| 12.08.2021 | Viktoria Plzen | 3-1/p.4-1 | The New Saints | |
| 05.08.2021 | The New Saints | 4-2 | Viktoria Plzen | |
Tobol Kostanay 0-6 MSK Zilina *
| 12.08.2021 | MSK Zilina | 5-0 | Tobol Kostanay | |
| 05.08.2021 | Tobol Kostanay | 0-1 | MSK Zilina | |
*Vitesse Arnhem 4-3 Dundalk FC
| 12.08.2021 | Dundalk FC | 1-2 | Vitesse Arnhem | |
| 05.08.2021 | Vitesse Arnhem | 2-2 | Dundalk FC | |