*AFC Ajax 7-1 Slovan Bratislava
| 27.08.2009 | Slovan Bratislava | 1-2 | AFC Ajax | |
| 20.08.2009 | AFC Ajax | 5-0 | Slovan Bratislava | |
MFK Kosice 4-10 AS Roma *
| 27.08.2009 | AS Roma | 7-1 | MFK Kosice | |
| 20.08.2009 | MFK Kosice | 3-3 | AS Roma | |
*Rapid Wien 2-2 Aston Villa
| 27.08.2009 | Aston Villa | 2-1 | Rapid Wien | |
| 20.08.2009 | Rapid Wien | 1-0 | Aston Villa | |
*Athletic Bilbao 4-3 Tromso IL
| 27.08.2009 | Tromso IL | 1-1 | Athletic Bilbao | |
| 20.08.2009 | Athletic Bilbao | 3-2 | Tromso IL | |
Metalurg Donetsk 4-5 Austria Wien *
| 27.08.2009 | Austria Wien | 3-2 AET | Metalurg Donetsk | |
| 20.08.2009 | Metalurg Donetsk | 2-2 | Austria Wien | |
*BATE Borisov 4-1 Litex Lovech
| 27.08.2009 | Litex Lovech | 0-4 AET | BATE Borisov | |
| 20.08.2009 | BATE Borisov | 0-1 | Litex Lovech | |
Bnei Yehuda 0-2 PSV Eindhoven *
| 27.08.2009 | PSV Eindhoven | 1-0 | Bnei Yehuda | |
| 20.08.2009 | Bnei Yehuda | 0-1 | PSV Eindhoven | |
Lech Poznan 1-1 Club Brugge *
| 27.08.2009 | Club Brugge | 1-0/p.4-3 | Lech Poznan | |
| 20.08.2009 | Lech Poznan | 1-0 | Club Brugge | |
*Dinamo Bucuresti 3-3 Slovan Liberec
| 27.08.2009 | Slovan Liberec | 0-3/p.8-9 | Dinamo Bucuresti | |
| 20.08.2009 | Dinamo Bucuresti | 0-3 | Slovan Liberec | |
*Dinamo Zagreb 4-2 Hearts FC
| 27.08.2009 | Hearts FC | 2-0 | Dinamo Zagreb | |
| 20.08.2009 | Dinamo Zagreb | 4-0 | Hearts FC | |
*CSKA Sofia 2-1 Dynamo Moscow
| 27.08.2009 | Dynamo Moscow | 1-2 | CSKA Sofia | |
| 20.08.2009 | CSKA Sofia | 0-0 | Dynamo Moscow | |
FC Sion 2-4 Fenerbahçe SK *
| 27.08.2009 | Fenerbahçe SK | 2-2 | FC Sion | |
| 20.08.2009 | FC Sion | 0-2 | Fenerbahçe SK | |
*FC Twente 3-1 Qarabag FK
| 27.08.2009 | Qarabag FK | 0-0 | FC Twente | |
| 20.08.2009 | FC Twente | 3-1 | Qarabag FK | |
FC Vaslui 2-4 AEK Athens *
| 27.08.2009 | AEK Athens | 3-0 | FC Vaslui | |
| 20.08.2009 | FC Vaslui | 2-1 | AEK Athens | |
*Slavia Praha 4-2 FK Crvena Zvezda
| 27.08.2009 | FK Crvena Zvezda | 2-1 | Slavia Praha | |
| 20.08.2009 | Slavia Praha | 3-0 | FK Crvena Zvezda | |
FK Sarajevo 2-3 CFR Cluj *
| 27.08.2009 | CFR Cluj | 2-1 | FK Sarajevo | |
| 20.08.2009 | FK Sarajevo | 1-1 | CFR Cluj | |
*Fulham 3-2 Amkar Perm
| 27.08.2009 | Amkar Perm | 1-0 | Fulham | |
| 20.08.2009 | Fulham | 3-1 | Amkar Perm | |
*Galatasaray SK 6-1 Levadia Tallinn
| 27.08.2009 | Levadia Tallinn | 1-1 | Galatasaray SK | |
| 20.08.2009 | Galatasaray SK | 5-0 | Levadia Tallinn | |
Guingamp 2-8 Hamburger SV *
| 27.08.2009 | Hamburger SV | 3-1 | Guingamp | |
| 20.08.2009 | Guingamp | 1-5 | Hamburger SV | |
Brøndby IF 3-4 Hertha BSC *
| 27.08.2009 | Hertha BSC | 3-1 | Brøndby IF | |
| 20.08.2009 | Brøndby IF | 2-1 | Hertha BSC | |
*Lazio 3-1 IF Elfsborg
| 27.08.2009 | IF Elfsborg | 1-0 | Lazio | |
| 20.08.2009 | Lazio | 3-0 | IF Elfsborg | |
Racing Genk 3-6 Lille OSC *
| 27.08.2009 | Lille OSC | 4-2 | Racing Genk | |
| 20.08.2009 | Racing Genk | 1-2 | Lille OSC | |
Maribor 0-3 Sparta Praha *
| 27.08.2009 | Sparta Praha | 1-0 | Maribor | |
| 20.08.2009 | Maribor | 0-2 | Sparta Praha | |
*Sturm Graz 2-1 Metalist Kharkiv
| 27.08.2009 | Metalist Kharkiv | 0-1 | Sturm Graz | |
| 20.08.2009 | Sturm Graz | 1-1 | Metalist Kharkiv | |
*FK Partizan 3-1 MSK Zilina
| 27.08.2009 | MSK Zilina | 0-2 | FK Partizan | |
| 20.08.2009 | FK Partizan | 1-1 | MSK Zilina | |
PAOK Salonica 1-1 SC Heerenveen *
| 27.08.2009 | SC Heerenveen | 0-0 | PAOK Salonica | |
| 20.08.2009 | PAOK Salonica | 1-1 | SC Heerenveen | |
*Everton 5-1 Sigma Olomouc
| 27.08.2009 | Sigma Olomouc | 1-1 | Everton | |
| 20.08.2009 | Everton | 4-0 | Sigma Olomouc | |
Sivasspor 0-5 Shakhtar Donetsk *
| 25.08.2009 | Shakhtar Donetsk | 2-0 | Sivasspor | |
| 20.08.2009 | Sivasspor | 0-3 | Shakhtar Donetsk | |
*SL Benfica 5-2 Vorskla
| 27.08.2009 | Vorskla | 2-1 | SL Benfica | |
| 20.08.2009 | SL Benfica | 4-0 | Vorskla | |
*Steaua Bucuresti 5-1 St Patrick's Dublin
| 27.08.2009 | St Patrick's Dublin | 1-2 | Steaua Bucuresti | |
| 20.08.2009 | Steaua Bucuresti | 3-0 | St Patrick's Dublin | |
Teplice 2-3 Hapoel Tel Aviv *
| 27.08.2009 | Hapoel Tel Aviv | 1-1 | Teplice | |
| 20.08.2009 | Teplice | 1-2 | Hapoel Tel Aviv | |
Trabzonspor 2-3 Toulouse FC *
| 27.08.2009 | Toulouse FC | 0-1 | Trabzonspor | |
| 20.08.2009 | Trabzonspor | 1-3 | Toulouse FC | |
Stabaek 1-7 Valencia CF *
| 27.08.2009 | Valencia CF | 4-1 | Stabaek | |
| 20.08.2009 | Stabaek | 0-3 | Valencia CF | |
NAC Breda 2-9 Villarreal CF *
| 27.08.2009 | Villarreal CF | 6-1 | NAC Breda | |
| 20.08.2009 | NAC Breda | 1-3 | Villarreal CF | |
*Werder Bremen 8-3 FK Aktobe
| 27.08.2009 | FK Aktobe | 0-2 | Werder Bremen | |
| 20.08.2009 | Werder Bremen | 6-3 | FK Aktobe | |
*Nacional Madeira 5-4 Zenit
| 27.08.2009 | Zenit | 1-1 | Nacional Madeira | |
| 20.08.2009 | Nacional Madeira | 4-3 | Zenit | |