*AZ Alkmaar 2-0 Anderlecht
| 23.02.2012 | Anderlecht | 0-1 | AZ Alkmaar | |
| 16.02.2012 | AZ Alkmaar | 1-0 | Anderlecht | |
Lazio 1-4 Atlético Madrid *
| 23.02.2012 | Atlético Madrid | 1-0 | Lazio | |
| 16.02.2012 | Lazio | 1-3 | Atlético Madrid | |
*Hannover 96 3-1 Club Brugge
| 23.02.2012 | Club Brugge | 0-1 | Hannover 96 | |
| 16.02.2012 | Hannover 96 | 2-1 | Club Brugge | |
Legia Warszawa 2-3 Sporting Lisboa *
| 23.02.2012 | Sporting Lisboa | 1-0 | Legia Warszawa | |
| 16.02.2012 | Legia Warszawa | 2-2 | Sporting Lisboa | |
Lokomotiv Moscow 2-2 Athletic Bilbao *
| 23.02.2012 | Athletic Bilbao | 1-0 | Lokomotiv Moscow | |
| 16.02.2012 | Lokomotiv Moscow | 2-1 | Athletic Bilbao | |
FC Porto 1-6 Manchester City *
| 22.02.2012 | Manchester City | 4-0 | FC Porto | |
| 16.02.2012 | FC Porto | 1-2 | Manchester City | |
AFC Ajax 2-3 Manchester United *
| 23.02.2012 | Manchester United | 1-2 | AFC Ajax | |
| 16.02.2012 | AFC Ajax | 0-2 | Manchester United | |
RB Salzburg 1-8 Metalist Kharkiv *
| 23.02.2012 | Metalist Kharkiv | 4-1 | RB Salzburg | |
| 16.02.2012 | RB Salzburg | 0-4 | Metalist Kharkiv | |
Rubin Kazan 0-2 Olympiakos Pireus *
| 23.02.2012 | Olympiakos Pireus | 1-0 | Rubin Kazan | |
| 14.02.2012 | Rubin Kazan | 0-1 | Olympiakos Pireus | |
SC Braga 1-2 Besiktas JK *
| 23.02.2012 | Besiktas JK | 0-1 | SC Braga | |
| 14.02.2012 | SC Braga | 0-2 | Besiktas JK | |
Viktoria Plzen 2-4 Schalke 04 *
| 23.02.2012 | Schalke 04 | 3-1 AET | Viktoria Plzen | |
| 16.02.2012 | Viktoria Plzen | 1-1 | Schalke 04 | |
Steaua Bucuresti 0-2 FC Twente *
| 23.02.2012 | FC Twente | 1-0 | Steaua Bucuresti | |
| 16.02.2012 | Steaua Bucuresti | 0-1 | FC Twente | |
Stoke City 0-2 Valencia CF *
| 23.02.2012 | Valencia CF | 1-0 | Stoke City | |
| 16.02.2012 | Stoke City | 0-1 | Valencia CF | |
Trabzonspor 2-6 PSV Eindhoven *
| 23.02.2012 | PSV Eindhoven | 4-1 | Trabzonspor | |
| 16.02.2012 | Trabzonspor | 1-2 | PSV Eindhoven | |
*Udinese Calcio 3-0 PAOK Salonica
| 23.02.2012 | PAOK Salonica | 0-3 | Udinese Calcio | |
| 16.02.2012 | Udinese Calcio | 0-0 | PAOK Salonica | |
Wisła Kraków 1-1 Standard Liège *
| 23.02.2012 | Standard Liège | 0-0 | Wisła Kraków | |
| 16.02.2012 | Wisła Kraków | 1-1 | Standard Liège | |