AFC Ajax 2-2 Steaua Bucuresti *
| 21.02.2013 | Steaua Bucuresti | 2-0/p.4-2 | AFC Ajax | |
| 14.02.2013 | AFC Ajax | 2-0 | Steaua Bucuresti | |
Atlético Madrid 1-2 Rubin Kazan *
| 21.02.2013 | Rubin Kazan | 0-1 | Atlético Madrid | |
| 14.02.2013 | Atlético Madrid | 0-2 | Rubin Kazan | |
BATE Borisov 0-1 Fenerbahçe SK *
| 21.02.2013 | Fenerbahçe SK | 1-0 | BATE Borisov | |
| 14.02.2013 | BATE Borisov | 0-0 | Fenerbahçe SK | |
Bayer Leverkusen 1-3 SL Benfica *
| 21.02.2013 | SL Benfica | 2-1 | Bayer Leverkusen | |
| 14.02.2013 | Bayer Leverkusen | 0-1 | SL Benfica | |
Sparta Praha 1-2 Chelsea FC *
| 21.02.2013 | Chelsea FC | 1-1 | Sparta Praha | |
| 14.02.2013 | Sparta Praha | 0-1 | Chelsea FC | |
Dynamo Kyiv 1-2 Girondins Bordeaux *
| 21.02.2013 | Girondins Bordeaux | 1-0 | Dynamo Kyiv | |
| 14.02.2013 | Dynamo Kyiv | 1-1 | Girondins Bordeaux | |
*Anzhi Makhachkala 4-2 Hannover 96
| 21.02.2013 | Hannover 96 | 1-1 | Anzhi Makhachkala | |
| 14.02.2013 | Anzhi Makhachkala | 3-1 | Hannover 96 | |
*Inter Milan 5-0 CFR Cluj
| 21.02.2013 | CFR Cluj | 0-3 | Inter Milan | |
| 14.02.2013 | Inter Milan | 2-0 | CFR Cluj | |
Mönchengladbach 3-5 Lazio *
| 21.02.2013 | Lazio | 2-0 | Mönchengladbach | |
| 14.02.2013 | Mönchengladbach | 3-3 | Lazio | |
*Newcastle United 1-0 Metalist Kharkiv
| 21.02.2013 | Metalist Kharkiv | 0-1 | Newcastle United | |
| 14.02.2013 | Newcastle United | 0-0 | Metalist Kharkiv | |
*Levante UD 4-0 Olympiakos Pireus
| 21.02.2013 | Olympiakos Pireus | 0-1 | Levante UD | |
| 14.02.2013 | Levante UD | 3-0 | Olympiakos Pireus | |
SSC Napoli 0-5 Viktoria Plzen *
| 21.02.2013 | Viktoria Plzen | 2-0 | SSC Napoli | |
| 14.02.2013 | SSC Napoli | 0-3 | Viktoria Plzen | |
*VfB Stuttgart 3-1 Racing Genk
| 21.02.2013 | Racing Genk | 0-2 | VfB Stuttgart | |
| 14.02.2013 | VfB Stuttgart | 1-1 | Racing Genk | |