Legia Warszawa 0-1 AFC Ajax *
| 23.02.2017 | AFC Ajax | 1-0 | Legia Warszawa | |
| 16.02.2017 | Legia Warszawa | 0-0 | AFC Ajax | |
*Olympiakos Pireus 3-0 Ankaraspor
| 23.02.2017 | Ankaraspor | 0-3 | Olympiakos Pireus | |
| 16.02.2017 | Olympiakos Pireus | 0-0 | Ankaraspor | |
Villarreal CF 1-4 AS Roma *
| 23.02.2017 | AS Roma | 0-1 | Villarreal CF | |
| 16.02.2017 | Villarreal CF | 0-4 | AS Roma | |
Astra Giurgiu 2-3 Racing Genk *
| 23.02.2017 | Racing Genk | 1-0 | Astra Giurgiu | |
| 16.02.2017 | Astra Giurgiu | 2-2 | Racing Genk | |
Athletic Bilbao 3-4 APOEL FC *
| 23.02.2017 | APOEL FC | 2-0 | Athletic Bilbao | |
| 16.02.2017 | Athletic Bilbao | 3-2 | APOEL FC | |
AZ Alkmaar 2-11 Lyon *
| 23.02.2017 | Lyon | 7-1 | AZ Alkmaar | |
| 16.02.2017 | AZ Alkmaar | 1-4 | Lyon | |
Hapoel Be'er Sheva 2-5 Besiktas JK *
| 23.02.2017 | Besiktas JK | 2-1 | Hapoel Be'er Sheva | |
| 16.02.2017 | Hapoel Be'er Sheva | 1-3 | Besiktas JK | |
Ludogorets 1-2 FC København *
| 23.02.2017 | FC København | 0-0 | Ludogorets | |
| 16.02.2017 | Ludogorets | 1-2 | FC København | |
*FK Krasnodar 2-1 Fenerbahçe SK
| 22.02.2017 | Fenerbahçe SK | 1-1 | FK Krasnodar | |
| 16.02.2017 | FK Krasnodar | 1-0 | Fenerbahçe SK | |
*Manchester United 4-0 AS Saint-Étienne
| 22.02.2017 | AS Saint-Étienne | 0-1 | Manchester United | |
| 16.02.2017 | Manchester United | 3-0 | AS Saint-Étienne | |
*Mönchengladbach 4-3 Fiorentina
| 23.02.2017 | Fiorentina | 2-4 | Mönchengladbach | |
| 16.02.2017 | Mönchengladbach | 0-1 | Fiorentina | |
PAOK Salonica 1-4 Schalke 04 *
| 22.02.2017 | Schalke 04 | 1-1 | PAOK Salonica | |
| 16.02.2017 | PAOK Salonica | 0-3 | Schalke 04 | |
*Celta de Vigo 2-1 Shakhtar Donetsk
| 23.02.2017 | Shakhtar Donetsk | 0-2 AET | Celta de Vigo | |
| 16.02.2017 | Celta de Vigo | 0-1 | Shakhtar Donetsk | |
*FK Rostov 5-1 Sparta Praha
| 23.02.2017 | Sparta Praha | 1-1 | FK Rostov | |
| 16.02.2017 | FK Rostov | 4-0 | Sparta Praha | |
*Anderlecht 3-3 Zenit
| 23.02.2017 | Zenit | 3-1 | Anderlecht | |
| 16.02.2017 | Anderlecht | 2-0 | Zenit | |