*AFC Ajax 4-3 Schalke 04
| 20.04.2017 | Schalke 04 | 3-2 AET | AFC Ajax | |
| 13.04.2017 | AFC Ajax | 2-0 | Schalke 04 | |
Anderlecht 2-3 Manchester United *
| 20.04.2017 | Manchester United | 2-1 AET | Anderlecht | |
| 13.04.2017 | Anderlecht | 1-1 | Manchester United | |
*Celta de Vigo 4-3 Racing Genk
| 20.04.2017 | Racing Genk | 1-1 | Celta de Vigo | |
| 13.04.2017 | Celta de Vigo | 3-2 | Racing Genk | |
*Lyon 3-3 Besiktas JK
| 20.04.2017 | Besiktas JK | 2-1/p.6-7 | Lyon | |
| 13.04.2017 | Lyon | 2-1 | Besiktas JK | |