AFC Ajax 2-3 AJ Auxerre
| 24.02.2005 | AJ Auxerre | 3-1 | AFC Ajax | |
| 16.02.2005 | AFC Ajax | 1-0 | AJ Auxerre | |
Alemannia Aachen 1-2 AZ Alkmaar
| 24.02.2005 | AZ Alkmaar | 2-1 | Alemannia Aachen | |
| 17.02.2005 | Alemannia Aachen | 0-0 | AZ Alkmaar | |
Austria Wien 2-1 Athletic Bilbao
| 27.02.2005 | Athletic Bilbao | 1-2 | Austria Wien | |
| 24.02.2005 | Austria Wien | 0-0 | Athletic Bilbao | |
FK Partizan 3-2 Dnipro
| 24.02.2005 | Dnipro | 0-1 | FK Partizan | |
| 16.02.2005 | FK Partizan | 2-2 | Dnipro | |
Sporting Lisboa 4-2 Feyenoord
| 24.02.2005 | Feyenoord | 1-2 | Sporting Lisboa | |
| 16.02.2005 | Sporting Lisboa | 2-1 | Feyenoord | |
Grazer AK 3-4 Middlesbrough
| 24.02.2005 | Middlesbrough | 2-1 | Grazer AK | |
| 17.02.2005 | Grazer AK | 2-2 | Middlesbrough | |
Olympiakos Pireus 2-0 FC Sochaux
| 24.02.2005 | FC Sochaux | 0-1 | Olympiakos Pireus | |
| 17.02.2005 | Olympiakos Pireus | 1-0 | FC Sochaux | |
*Parma FC 2-0 VfB Stuttgart
| 24.02.2005 | VfB Stuttgart | 0-2 AET | Parma FC | |
| 16.02.2005 | Parma FC | 0-0 | VfB Stuttgart | |
Fenerbahçe SK 1-3 Real Zaragoza
| 24.02.2005 | Real Zaragoza | 2-1 | Fenerbahçe SK | |
| 17.02.2005 | Fenerbahçe SK | 0-1 | Real Zaragoza | |
SC Heerenveen 2-4 Newcastle United
| 24.02.2005 | Newcastle United | 2-1 | SC Heerenveen | |
| 17.02.2005 | SC Heerenveen | 1-2 | Newcastle United | |
Shakhtar Donetsk 2-1 Schalke 04
| 24.02.2005 | Schalke 04 | 0-1 | Shakhtar Donetsk | |
| 16.02.2005 | Shakhtar Donetsk | 1-1 | Schalke 04 | |
Panathinaikos 1-2 Sevilla FC
| 24.02.2005 | Sevilla FC | 2-0 | Panathinaikos | |
| 16.02.2005 | Panathinaikos | 1-0 | Sevilla FC | |
CSKA Moscow 3-1 SL Benfica
| 24.02.2005 | SL Benfica | 1-1 | CSKA Moscow | |
| 17.02.2005 | CSKA Moscow | 2-0 | SL Benfica | |
Valencia CF 2-2 Steaua Bucuresti *
| 24.02.2005 | Steaua Bucuresti | 2-0/p.4-3 | Valencia CF | |
| 16.02.2005 | Valencia CF | 2-0 | Steaua Bucuresti | |
Dynamo Kyiv 0-2 Villarreal CF
| 24.02.2005 | Villarreal CF | 2-0 | Dynamo Kyiv | |
| 17.02.2005 | Dynamo Kyiv | 0-0 | Villarreal CF | |