*Bolton Wanderers 1-0 Atlético Madrid
| 21.02.2008 | Atlético Madrid | 0-0 | Bolton Wanderers | |
| 14.02.2008 | Bolton Wanderers | 1-0 | Atlético Madrid | |
Galatasaray SK 1-5 Bayer Leverkusen *
| 21.02.2008 | Bayer Leverkusen | 5-1 | Galatasaray SK | |
| 13.02.2008 | Galatasaray SK | 0-0 | Bayer Leverkusen | |
Aberdeen FC 3-7 Bayern München *
| 21.02.2008 | Bayern München | 5-1 | Aberdeen FC | |
| 14.02.2008 | Aberdeen FC | 2-2 | Bayern München | |
*Sporting Lisboa 5-0 FC Basel
| 21.02.2008 | FC Basel | 0-3 | Sporting Lisboa | |
| 13.02.2008 | Sporting Lisboa | 2-0 | FC Basel | |
FC Zürich 1-3 Hamburger SV *
| 21.02.2008 | Hamburger SV | 0-0 | FC Zürich | |
| 14.02.2008 | FC Zürich | 1-3 | Hamburger SV | |
Rosenborg BK 1-3 Fiorentina *
| 21.02.2008 | Fiorentina | 2-1 | Rosenborg BK | |
| 14.02.2008 | Rosenborg BK | 0-1 | Fiorentina | |
AEK Athens 1-4 Getafe CF *
| 21.02.2008 | Getafe CF | 3-0 | AEK Athens | |
| 13.02.2008 | AEK Athens | 1-1 | Getafe CF | |
*Anderlecht 3-2 Girondins Bordeaux
| 21.02.2008 | Girondins Bordeaux | 1-1 | Anderlecht | |
| 13.02.2008 | Anderlecht | 2-1 | Girondins Bordeaux | |
*PSV Eindhoven 4-1 Helsingborg
| 21.02.2008 | Helsingborg | 1-2 | PSV Eindhoven | |
| 13.02.2008 | PSV Eindhoven | 2-0 | Helsingborg | |
*Olympique Marseille 3-2 Spartak Moscow
| 21.02.2008 | Spartak Moscow | 2-0 | Olympique Marseille | |
| 13.02.2008 | Olympique Marseille | 3-0 | Spartak Moscow | |
*Rangers FC 1-1 Panathinaikos
| 21.02.2008 | Panathinaikos | 1-1 | Rangers FC | |
| 13.02.2008 | Rangers FC | 0-0 | Panathinaikos | |
*Werder Bremen 4-0 SC Braga
| 21.02.2008 | SC Braga | 0-1 | Werder Bremen | |
| 13.02.2008 | Werder Bremen | 3-0 | SC Braga | |
*SL Benfica 3-2 Nürnberg
| 21.02.2008 | Nürnberg | 2-2 | SL Benfica | |
| 14.02.2008 | SL Benfica | 1-0 | Nürnberg | |
Slavia Praha 2-3 Tottenham *
| 21.02.2008 | Tottenham | 1-1 | Slavia Praha | |
| 14.02.2008 | Slavia Praha | 1-2 | Tottenham | |
*Zenit 2-2 Villarreal CF
| 21.02.2008 | Villarreal CF | 2-1 | Zenit | |
| 13.02.2008 | Zenit | 1-0 | Villarreal CF | |