APOEL FC 2-5 Schalke 04 *
| 02.10.2008 | Schalke 04 | 1-1 | APOEL FC | |
| 16.09.2008 | APOEL FC | 1-4 | Schalke 04 | |
*AS Nancy-Lorraine 3-0 Motherwell FC
| 02.10.2008 | Motherwell FC | 0-2 | AS Nancy-Lorraine | |
| 18.09.2008 | AS Nancy-Lorraine | 1-0 | Motherwell FC | |
Austria Wien 4-5 Lech Poznan *
| 02.10.2008 | Lech Poznan | 4-2 AET | Austria Wien | |
| 18.09.2008 | Austria Wien | 2-1 | Lech Poznan | |
Banik Ostrava 1-2 Spartak Moscow *
| 02.10.2008 | Spartak Moscow | 1-1 | Banik Ostrava | |
| 18.09.2008 | Banik Ostrava | 0-1 | Spartak Moscow | |
Borac Cacak 1-6 AFC Ajax *
| 02.10.2008 | AFC Ajax | 2-0 | Borac Cacak | |
| 18.09.2008 | Borac Cacak | 1-4 | AFC Ajax | |
Brøndby IF 3-5 Rosenborg BK *
| 02.10.2008 | Rosenborg BK | 3-2 | Brøndby IF | |
| 18.09.2008 | Brøndby IF | 1-2 | Rosenborg BK | |
Cherno More Varna 3-4 VfB Stuttgart *
| 02.10.2008 | VfB Stuttgart | 2-2 | Cherno More Varna | |
| 18.09.2008 | Cherno More Varna | 1-2 | VfB Stuttgart | |
BSC Young Boys 2-4 Club Brugge *
| 02.10.2008 | Club Brugge | 2-0 | BSC Young Boys | |
| 18.09.2008 | BSC Young Boys | 2-2 | Club Brugge | |
Slaven Belupo 1-3 CSKA Moscow *
| 30.09.2008 | CSKA Moscow | 1-0 | Slaven Belupo | |
| 18.09.2008 | Slaven Belupo | 1-2 | CSKA Moscow | |
SK Brann 2-2 Deportivo La Coruña *
| 02.10.2008 | Deportivo La Coruña | 2-0/p.3-2 | SK Brann | |
| 18.09.2008 | SK Brann | 2-0 | Deportivo La Coruña | |
*NEC Nijmegen 1-0 Dinamo Bucuresti
| 02.10.2008 | Dinamo Bucuresti | 0-0 | NEC Nijmegen | |
| 18.09.2008 | NEC Nijmegen | 1-0 | Dinamo Bucuresti | |
*Dinamo Zagreb 3-3 Sparta Praha
| 02.10.2008 | Sparta Praha | 3-3 | Dinamo Zagreb | |
| 18.09.2008 | Dinamo Zagreb | 0-0 | Sparta Praha | |
Everton 3-4 Standard Liège *
| 02.10.2008 | Standard Liège | 2-1 | Everton | |
| 18.09.2008 | Everton | 2-2 | Standard Liège | |
*Sampdoria 7-1 FBK Kaunas
| 02.10.2008 | FBK Kaunas | 1-2 | Sampdoria | |
| 18.09.2008 | Sampdoria | 5-0 | FBK Kaunas | |
FK Moscow 2-3 FC København *
| 02.10.2008 | FC København | 1-1 | FK Moscow | |
| 18.09.2008 | FK Moscow | 1-2 | FC København | |
Stade Rennais 2-2 FC Twente *
| 02.10.2008 | FC Twente | 1-0 | Stade Rennais | |
| 18.09.2008 | Stade Rennais | 2-1 | FC Twente | |
FC Timisoara 1-3 FK Partizan *
| 02.10.2008 | FK Partizan | 1-0 | FC Timisoara | |
| 18.09.2008 | FC Timisoara | 1-2 | FK Partizan | |
AC Bellinzona 4-6 Galatasaray SK *
| 02.10.2008 | Galatasaray SK | 2-1 | AC Bellinzona | |
| 18.09.2008 | AC Bellinzona | 3-4 | Galatasaray SK | |
*Hamburger SV 2-0 Unirea Urziceni
| 02.10.2008 | Unirea Urziceni | 0-2 | Hamburger SV | |
| 18.09.2008 | Hamburger SV | 0-0 | Unirea Urziceni | |
Hapoel Tel Aviv 2-4 AS Saint-Étienne *
| 02.10.2008 | AS Saint-Étienne | 2-1 | Hapoel Tel Aviv | |
| 18.09.2008 | Hapoel Tel Aviv | 1-2 | AS Saint-Étienne | |
Litex Lovech 2-4 Aston Villa *
| 02.10.2008 | Aston Villa | 1-1 | Litex Lovech | |
| 18.09.2008 | Litex Lovech | 1-3 | Aston Villa | |
Omonia Nicosia 2-4 Manchester City *
| 02.10.2008 | Manchester City | 2-1 | Omonia Nicosia | |
| 18.09.2008 | Omonia Nicosia | 1-2 | Manchester City | |
Besiktas JK 2-4 Metalist Kharkiv *
| 02.10.2008 | Metalist Kharkiv | 4-1 | Besiktas JK | |
| 18.09.2008 | Besiktas JK | 1-0 | Metalist Kharkiv | |
*MSK Zilina 2-1 Levski Sofia
| 02.10.2008 | Levski Sofia | 0-1 | MSK Zilina | |
| 18.09.2008 | MSK Zilina | 1-1 | Levski Sofia | |
FC Nordsjælland 0-7 Olympiakos Pireus *
| 02.10.2008 | Olympiakos Pireus | 5-0 | FC Nordsjælland | |
| 16.09.2008 | FC Nordsjælland | 0-2 | Olympiakos Pireus | |
Kayserispor 1-2 Paris St. Germain *
| 02.10.2008 | Paris St. Germain | 0-0 | Kayserispor | |
| 18.09.2008 | Kayserispor | 1-2 | Paris St. Germain | |
*Racing Santander 2-0 FC Honka Espoo
| 02.10.2008 | FC Honka Espoo | 0-1 | Racing Santander | |
| 18.09.2008 | Racing Santander | 1-0 | FC Honka Espoo | |
*SC Braga 6-0 FC Artmedia Petržalka
| 02.10.2008 | FC Artmedia Petržalka | 0-2 | SC Braga | |
| 18.09.2008 | SC Braga | 4-0 | FC Artmedia Petržalka | |
*Sevilla FC 4-0 RB Salzburg
| 02.10.2008 | RB Salzburg | 0-2 | Sevilla FC | |
| 18.09.2008 | Sevilla FC | 2-0 | RB Salzburg | |
*Slavia Praha 1-1 SC Vaslui
| 02.10.2008 | SC Vaslui | 1-1 | Slavia Praha | |
| 18.09.2008 | Slavia Praha | 0-0 | SC Vaslui | |
SSC Napoli 3-4 SL Benfica *
| 02.10.2008 | SL Benfica | 2-0 | SSC Napoli | |
| 18.09.2008 | SSC Napoli | 3-2 | SL Benfica | |
*Hertha BSC 2-0 St Patrick's Dublin
| 30.09.2008 | St Patrick's Dublin | 0-0 | Hertha BSC | |
| 16.09.2008 | Hertha BSC | 2-0 | St Patrick's Dublin | |
*Tottenham 3-2 Wisła Kraków
| 02.10.2008 | Wisła Kraków | 1-1 | Tottenham | |
| 18.09.2008 | Tottenham | 2-1 | Wisła Kraków | |
Borussia Dortmund 2-2 Udinese Calcio *
| 02.10.2008 | Udinese Calcio | 0-2/p.4-3 | Borussia Dortmund | |
| 18.09.2008 | Borussia Dortmund | 0-2 | Udinese Calcio | |
Marítimo 1-3 Valencia CF *
| 02.10.2008 | Valencia CF | 2-1 | Marítimo | |
| 18.09.2008 | Marítimo | 0-1 | Valencia CF | |
*VfL Wolfsburg 2-1 Rapid Bucuresti
| 02.10.2008 | Rapid Bucuresti | 1-1 | VfL Wolfsburg | |
| 18.09.2008 | VfL Wolfsburg | 1-0 | Rapid Bucuresti | |
*Portsmouth 4-2 Vitória Guimarães
| 02.10.2008 | Vitória Guimarães | 2-2 AET | Portsmouth | |
| 18.09.2008 | Portsmouth | 2-0 | Vitória Guimarães | |
Vitória Setúbal 3-6 SC Heerenveen *
| 02.10.2008 | SC Heerenveen | 5-2 | Vitória Setúbal | |
| 18.09.2008 | Vitória Setúbal | 1-1 | SC Heerenveen | |