Bylis Ballsh 3-3 Skenderbeu *
| 17.11.2021 | Skenderbeu | 2-2/p.4-3 | Bylis Ballsh | |
| 03.11.2021 | Bylis Ballsh | 1-1 | Skenderbeu | |
*Dinamo Tirana 2-2 KF Tirana
| 18.11.2021 | KF Tirana | 2-0/p.7-8 | Dinamo Tirana | |
| 03.11.2021 | Dinamo Tirana | 2-0 | KF Tirana | |
*Egnatia Rrogozhinë 3-2 FK Kukesi
| 17.11.2021 | FK Kukesi | 1-0 | Egnatia Rrogozhinë | |
| 03.11.2021 | Egnatia Rrogozhinë | 3-1 | FK Kukesi | |
Tomori Berat 1-2 KF Laci *
| 17.11.2021 | KF Laci | 1-1 | Tomori Berat | |
| 03.11.2021 | Tomori Berat | 0-1 | KF Laci | |
Korabi Peshkopi 0-3 KF Teuta Durres *
| 17.11.2021 | KF Teuta Durres | 2-0 | Korabi Peshkopi | |
| 03.11.2021 | Korabi Peshkopi | 0-1 | KF Teuta Durres | |
*Flamurtari Vlore 4-2 KS Kastrioti
| 17.11.2021 | KS Kastrioti | 2-4 | Flamurtari Vlore | |
| 03.11.2021 | Flamurtari Vlore | 0-0 | KS Kastrioti | |
KS Pogradeci 1-8 Vllaznia Shkodër *
| 17.11.2021 | Vllaznia Shkodër | 6-1 | KS Pogradeci | |
| 03.11.2021 | KS Pogradeci | 0-2 | Vllaznia Shkodër | |
Beselidhja Lezhe 0-3 Partizani Tirana *
| 17.11.2021 | Partizani Tirana | 2-0 | Beselidhja Lezhe | |
| 03.11.2021 | Beselidhja Lezhe | 0-1 | Partizani Tirana | |