Club Destroyers 1-8 CD San José *
| 12.05.2018 | CD San José | 8-0/p.4-2 | Club Destroyers | |
| 07.05.2018 | Club Destroyers | 1-0 | CD San José | |
*Jorge Wilstermann 6-1 Blooming
| 14.05.2018 | Blooming | 1-3 | Jorge Wilstermann | |
| 06.05.2018 | Jorge Wilstermann | 3-0 | Blooming | |
Nacional Potosí 1-3 Bolívar *
| 13.05.2018 | Bolívar | 1-0 | Nacional Potosí | |
| 06.05.2018 | Nacional Potosí | 1-2 | Bolívar | |
Oriente Petrolero 1-6 The Strongest *
| 12.05.2018 | The Strongest | 5-1 | Oriente Petrolero | |
| 06.05.2018 | Oriente Petrolero | 0-1 | The Strongest | |