Remo/PA 1-4 Atlético Mineiro/MG *
| 11.06.2021 | Atlético Mineiro/MG | 2-1 | Remo/PA | |
| 03.06.2021 | Remo/PA | 0-2 | Atlético Mineiro/MG | |
Corinthians/SP 0-2 Atlético/GO *
| 10.06.2021 | Atlético/GO | 0-0 | Corinthians/SP | |
| 03.06.2021 | Corinthians/SP | 0-2 | Atlético/GO | |
Avai FC/SC 1-2 Athletico/PR *
| 10.06.2021 | Athletico/PR | 1-0 | Avai FC/SC | |
| 04.06.2021 | Avai FC/SC | 1-1 | Athletico/PR | |
Vila Nova/GO 0-2 Bahia/BA *
| 10.06.2021 | Bahia/BA | 1-0 | Vila Nova/GO | |
| 01.06.2021 | Vila Nova/GO | 0-1 | Bahia/BA | |
Boavista/RJ 1-2 Vasco da Gama/RJ *
| 09.06.2021 | Vasco da Gama/RJ | 1-1 | Boavista/RJ | |
| 02.06.2021 | Boavista/RJ | 0-1 | Vasco da Gama/RJ | |
Chapecoense/SC 3-4 ABC Natal/RN *
| 09.06.2021 | ABC Natal/RN | 3-0 | Chapecoense/SC | |
| 02.06.2021 | Chapecoense/SC | 3-1 | ABC Natal/RN | |
*CRB/AL 1-1 Palmeiras/SP
| 10.06.2021 | Palmeiras/SP | 0-1/p.3-4 | CRB/AL | |
| 04.06.2021 | CRB/AL | 0-1 | Palmeiras/SP | |
América Mineiro/MG 2-2 Criciúma/SC *
| 10.06.2021 | Criciúma/SC | 2-2/p.3-2 | América Mineiro/MG | |
| 03.06.2021 | América Mineiro/MG | 0-0 | Criciúma/SC | |
Coritiba/PR 0-3 Flamengo/RJ *
| 17.06.2021 | Flamengo/RJ | 2-0 | Coritiba/PR | |
| 11.06.2021 | Coritiba/PR | 0-1 | Flamengo/RJ | |
*Fluminense/RJ 3-2 RB Bragantino/SP
| 10.06.2021 | RB Bragantino/SP | 2-1 | Fluminense/RJ | |
| 03.06.2021 | Fluminense/RJ | 2-0 | RB Bragantino/SP | |
*Fortaleza/CE 4-1 Ceará SC/CE
| 11.06.2021 | Ceará SC/CE | 0-3 | Fortaleza/CE | |
| 03.06.2021 | Fortaleza/CE | 1-1 | Ceará SC/CE | |
*Grêmio/RS 2-0 Brasiliense/DF
| 10.06.2021 | Brasiliense/DF | 0-0 | Grêmio/RS | |
| 02.06.2021 | Grêmio/RS | 2-0 | Brasiliense/DF | |
Cruzeiro/MG 1-1 Juazeirense/BA *
| 10.06.2021 | Juazeirense/BA | 1-0/p.3-2 | Cruzeiro/MG | |
| 03.06.2021 | Cruzeiro/MG | 1-0 | Juazeirense/BA | |
Cianorte/PR 0-3 Santos/SP *
| 08.06.2021 | Santos/SP | 1-0 | Cianorte/PR | |
| 02.06.2021 | Cianorte/PR | 0-2 | Santos/SP | |
4 de Julho/PI 4-11 São Paulo/SP *
| 09.06.2021 | São Paulo/SP | 9-1 | 4 de Julho/PI | |
| 02.06.2021 | 4 de Julho/PI | 3-2 | São Paulo/SP | |
*Vitória/BA 3-2 Internacional/RS
| 11.06.2021 | Internacional/RS | 1-3 | Vitória/BA | |
| 04.06.2021 | Vitória/BA | 0-1 | Internacional/RS | |