Salgueiro/PE 2-2 Altos/PI *
| 27.12.2020 | Altos/PI | 1-1/p.4-2 | Salgueiro/PE | |
| 20.12.2020 | Salgueiro/PE | 1-1 | Altos/PI | |
Galvez/AC 2-6 América/RN *
| 27.12.2020 | América/RN | 5-1 | Galvez/AC | |
| 20.12.2020 | Galvez/AC | 1-1 | América/RN | |
*Mirassol/SP 5-2 Brasiliense/DF
| 27.12.2020 | Brasiliense/DF | 2-1 | Mirassol/SP | |
| 20.12.2020 | Mirassol/SP | 4-0 | Brasiliense/DF | |
Globo FC/RN 2-2 Fast Clube/AM *
| 26.12.2020 | Fast Clube/AM | 1-0/p.6-5 | Globo FC/RN | |
| 20.12.2020 | Globo FC/RN | 2-1 | Fast Clube/AM | |
*Marcilio Dias/SC 3-2 Goianésia/GO
| 27.12.2020 | Goianésia/GO | 1-1 | Marcilio Dias/SC | |
| 19.12.2020 | Marcilio Dias/SC | 2-1 | Goianésia/GO | |
Juventude/MA 2-4 Floresta/CE *
| 27.12.2020 | Floresta/CE | 2-0 | Juventude/MA | |
| 20.12.2020 | Juventude/MA | 2-2 | Floresta/CE | |
Goiânia/GO 1-5 Novorizontino/SP *
| 27.12.2020 | Novorizontino/SP | 4-0 | Goiânia/GO | |
| 19.12.2020 | Goiânia/GO | 1-1 | Novorizontino/SP | |
São Luiz/RS 2-5 Aparecidense/GO *
| 27.12.2020 | Aparecidense/GO | 1-2 | São Luiz/RS | |
| 20.12.2020 | São Luiz/RS | 0-4 | Aparecidense/GO | |