*Bumamuru FC 3-2 Le Messager Ngozi
| 09.05.2021 | Le Messager Ngozi | 1-0 | Bumamuru FC | |
| 04.05.2021 | Bumamuru FC | 3-1 | Le Messager Ngozi | |
Garage Express 0-5 Flambeau du Centre *
| 09.05.2021 | Flambeau du Centre | 1-0 | Garage Express | |
| 05.05.2021 | Garage Express | 0-4 | Flambeau du Centre | |
*Musongati FC 3-0 Olympique Star
| 09.05.2021 | Olympique Star | 0-1 | Musongati FC | |
| 04.05.2021 | Musongati FC | 2-0 | Olympique Star | |
*Vital'O FC 3-1 Royal FC (BDI)
| 08.05.2021 | Royal FC (BDI) | 1-2 | Vital'O FC | |
| 04.05.2021 | Vital'O FC | 1-0 | Royal FC (BDI) | |