*CD Trasandino 1-1 Provincial Ovalle
| 13.11.2021 | Provincial Ovalle | 1-1/p.1-3 | CD Trasandino | |
| 05.11.2021 | CD Trasandino | 0-0 | Provincial Ovalle | |
Lota Schwager 1-2 Municipal Mejillones *
| 13.11.2021 | Municipal Mejillones | 2-1 | Lota Schwager | |
| 07.11.2021 | Lota Schwager | 0-0 | Municipal Mejillones | |
Municipal Santiago 3-5 Real San Joaquín *
| 13.11.2021 | Real San Joaquín | 3-0 | Municipal Santiago | |
| 06.11.2021 | Municipal Santiago | 3-2 | Real San Joaquín | |
*Provincial Ranco 6-4 Deportes Rengo
| 13.11.2021 | Deportes Rengo | 3-3 | Provincial Ranco | |
| 07.11.2021 | Provincial Ranco | 3-1 | Deportes Rengo | |