AD San Carlos 2-4 CS Herediano *
| 21.11.2010 | CS Herediano | 4-0 | AD San Carlos | |
| 14.11.2010 | AD San Carlos | 2-0 | CS Herediano | |
Brujas FC 3-4 CS Cartaginés
| 21.11.2010 | CS Cartaginés | 1-1 | Brujas FC | |
| 13.11.2010 | Brujas FC | 2-3 | CS Cartaginés | |
Pérez Zeledón 3-6 LD Alajuelense
| 21.11.2010 | LD Alajuelense | 4-1 | Pérez Zeledón | |
| 14.11.2010 | Pérez Zeledón | 2-2 | LD Alajuelense | |
Santos Guápiles 6-0 AD Barrio México
| 20.11.2010 | AD Barrio México | 0-3 W.O. | Santos Guápiles | |
| 13.11.2010 | Santos Guápiles | 3-0 W.O. | AD Barrio México | |