Marte Soyapango 1-3 AD Destroyer *
| 23.05.2021 | AD Destroyer | 3-1 | Marte Soyapango | |
| 15.05.2021 | Marte Soyapango | 0-0 | AD Destroyer | |
*Fuerte San Francisco 2-2 CD Aspirante
| 23.05.2021 | CD Aspirante | 1-1/p.6-7 | Fuerte San Francisco | |
| 16.05.2021 | Fuerte San Francisco | 1-1 | CD Aspirante | |
*San Pablo Tacachico 3-1 CD Titán
| 23.05.2021 | CD Titán | 1-0 | San Pablo Tacachico | |
| 16.05.2021 | San Pablo Tacachico | 3-0 | CD Titán | |
CD Liberal 2-3 Platense (SLV) *
| 23.05.2021 | Platense (SLV) | 1-1 | CD Liberal | |
| 16.05.2021 | CD Liberal | 1-2 | Platense (SLV) | |