*CD Rácing Jr 3-2 AD Destroyer
| 08.05.2022 | AD Destroyer | 1-2 | CD Rácing Jr | |
| 01.05.2022 | CD Rácing Jr | 1-1 | AD Destroyer | |
CD San Pablo Municipal 2-4 AD Ínter Sivar *
| 08.05.2022 | AD Ínter Sivar | 2-1 | CD San Pablo Municipal | |
| 01.05.2022 | CD San Pablo Municipal | 1-2 | AD Ínter Sivar | |
Fuerte San Francisco 2-3 CD Cacahuatique *
| 08.05.2022 | CD Cacahuatique | 2-2 | Fuerte San Francisco | |
| 01.05.2022 | Fuerte San Francisco | 0-1 | CD Cacahuatique | |
Marte Soyapango 1-2 CD Dragon (SLV) *
| 08.05.2022 | CD Dragon (SLV) | 1-0 | Marte Soyapango | |
| 01.05.2022 | Marte Soyapango | 1-1 | CD Dragon (SLV) | |