| 29.08.2018 | |||
| 21:00 | Reading FC | 0-2 | Watford FC |
| 20:45 | Everton | 3-1 | Rotherham |
| 20:45 | Millwall FC | 3-2 | Plymouth Argyle |
| 20:45 | Nottingham Forest | 3-1 | Newcastle United |
| 28.08.2018 | |||
| 21:00 | Stoke City | 2-0 | Huddersfield |
| 21:00 | West Bromwich | 2-1 | Mansfield |
| 20:45 | AFC Wimbledon | 1-3 | West Ham |
| 20:45 | Blackburn Rovers | 4-1 | Lincoln City |
| 20:45 | Bournemouth | 3-0 | Milton Keynes Dons |
| 20:45 | Brentford FC | 1-0 | Cheltenham |
| 20:45 | Brighton | 0-1 | Southampton |
| 20:45 | Burton Albion | 1-0 | Aston Villa |
| 20:45 | Cardiff City | 1-3 | Norwich City |
| 20:45 | Doncaster Rovers | 1-2 | Blackpool |
| 20:45 | Fulham | 2-0 | Exeter City |
| 20:45 | Hull City | 0-4 | Derby County |
| 20:45 | Leeds United | 0-2 | Preston NE |
| 20:45 | Leicester City | 4-0 | Fleetwood Town |
| 20:45 | Middlesbrough | 2-1 | Rochdale |
| 20:45 | Newport County | 0-3 | Oxford United |
| 20:45 | QPR | 3-1 | Bristol Rovers |
| 20:45 | Sheffield Wed | 0-2 | Wolverhampton |
| 20:45 | Walsall FC | 3-3/p.1-3 | Macclesfield |
| 20:45 | Wycombe | 2-2/p.4-3 | Forest Green |
| 20:30 | Swansea City | 0-1 | Crystal Palace |
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