AE Larisa 1-4 Asteras Tripoli *
| 22.12.2012 | Asteras Tripoli | 4-1 | AE Larisa | |
| 12.12.2012 | AE Larisa | 0-0 | Asteras Tripoli | |
Tyrnavos 2005 0-2 AO Kerkyra *
| 20.12.2012 | AO Kerkyra | 0-0 | Tyrnavos 2005 | |
| 29.11.2012 | Tyrnavos 2005 | 0-2 | AO Kerkyra | |
*AO Platanias 4-1 Anagennisi Karditsa
| 23.12.2012 | Anagennisi Karditsa | 0-1 | AO Platanias | |
| 13.12.2012 | AO Platanias | 3-1 | Anagennisi Karditsa | |
*Olympiakos Volos 3-3 Atromitos FC
| 22.12.2012 | Atromitos FC | 2-2 | Olympiakos Volos | |
| 12.12.2012 | Olympiakos Volos | 1-1 | Atromitos FC | |
Ethnikos Gazoros 2-2 SKODA Xanthi *
| 23.12.2012 | SKODA Xanthi | 1-1/p.5-4 | Ethnikos Gazoros | |
| 13.12.2012 | Ethnikos Gazoros | 1-1 | SKODA Xanthi | |
*Kallithea FC 4-3 Aris Salonica
| 23.12.2012 | Aris Salonica | 2-1 | Kallithea FC | |
| 12.12.2012 | Kallithea FC | 3-1 | Aris Salonica | |
*Kavala FC 1-0 AEK Athens
| 20.12.2012 | AEK Athens | 0-1 | Kavala FC | |
| 13.12.2012 | Kavala FC | 0-0 | AEK Athens | |
OFI Creta 1-2 Apollon Smyrni *
| 22.12.2012 | Apollon Smyrni | 2-0 AET | OFI Creta | |
| 28.11.2012 | OFI Creta | 1-0 | Apollon Smyrni | |
*Olympiakos Pireus 5-0 Panachaiki FC
| 19.12.2012 | Panachaiki FC | 0-3 W.O. | Olympiakos Pireus | |
| 28.11.2012 | Olympiakos Pireus | 2-0 | Panachaiki FC | |
*Panathinaikos 6-1 Proodeftiki
| 19.12.2012 | Proodeftiki | 1-2 | Panathinaikos | |
| 29.11.2012 | Panathinaikos | 4-0 | Proodeftiki | |
*Fostiras 2-2 Panionios GSS
| 19.12.2012 | Panionios GSS | 2-1 | Fostiras | |
| 28.11.2012 | Fostiras | 1-0 | Panionios GSS | |
*PAS Giannina 3-0 Panserraikos
| 23.12.2012 | Panserraikos | 0-2 | PAS Giannina | |
| 29.11.2012 | PAS Giannina | 1-0 | Panserraikos | |
*Panthrakikos 3-1 Niki Volos
| 19.12.2012 | Niki Volos | 1-1 | Panthrakikos | |
| 29.11.2012 | Panthrakikos | 2-0 | Niki Volos | |
Aiginiakos FC 2-5 PAOK Salonica *
| 22.12.2012 | PAOK Salonica | 2-1 | Aiginiakos FC | |
| 13.12.2012 | Aiginiakos FC | 1-3 | PAOK Salonica | |
*Levadiakos 7-0 Pierikos FC
| 20.12.2012 | Pierikos FC | 0-5 | Levadiakos | |
| 28.11.2012 | Levadiakos | 2-0 | Pierikos FC | |
*Veria NFC 2-0 Thrasyvoulos
| 20.12.2012 | Thrasyvoulos | 0-2 | Veria NFC | |
| 12.12.2012 | Veria NFC | 0-0 | Thrasyvoulos | |